{ "Cellosaurus": { "cell-line-list": [ { "accession-list": [ { "type": "primary", "value": "CVCL_1775" } ], "age": "37Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Population", "value": "Caucasian" }, { "category": "Part of", "value": "COSMIC cell lines project" }, { "category": "Part of", "value": "Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)" } ], "created": "2012-04-04", "derived-from": [ { "accession": "CVCL_0007", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "U-937", "url": "https://www.cellosaurus.org/CVCL_0007" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Pleural effusion", "xref-list": [ { "accession": "UBERON_0000175", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000175", "label": "pleural effusion", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000175" } ] } } ], "disease-list": [ { "accession": "C8263", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C8263", "label": "Adult acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8263" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "39", "genome-ancestry": { "population-list": [ { "population-name": "African", "population-percentage": "0" }, { "population-name": "Native American", "population-percentage": "0.04" }, { "population-name": "East Asian, North", "population-percentage": "0.5" }, { "population-name": "East Asian, South", "population-percentage": "0" }, { "population-name": "South Asian", "population-percentage": "1.33" }, { "population-name": "European, North", "population-percentage": "75.18" }, { "population-name": "European, South", "population-percentage": "22.94" } ], "source": { "reference": { "resource-internal-ref": "PubMed=30894373" } } }, "last-updated": "2025-04-10", "microsatellite-instability-list": [ { "msi-value": "Instable (MSI-high)", "source-list": [ { "institution": "Sanger", "value": "Sanger" } ] } ], "name-list": [ { "type": "identifier", "value": "TUR" }, { "type": "synonym", "value": "TPA-U937-resistant" } ], "omics-list": [ { "branch": "Genomics", "value": "DNA methylation analysis." }, { "branch": "Genomics", "value": "Whole exome sequencing." }, { "branch": "Phenotyping", "value": "Drug screening." }, { "branch": "Proteomics", "value": "Quantitative." }, { "branch": "Transcriptomics", "value": "Microarray." }, { "branch": "Variations", "value": "SNP array analysis." } ], "reference-list": [ { "resource-internal-ref": "PubMed=7720732" }, { "resource-internal-ref": "PubMed=8398907" }, { "resource-internal-ref": "PubMed=20164919" }, { "resource-internal-ref": "PubMed=27397505" }, { "resource-internal-ref": "PubMed=30894373" }, { "resource-internal-ref": "PubMed=35839778" } ], "sequence-variation-list": [ { "mutation-description": "PICALM-MLLT10, CALM-AF10", "source-list": [ { "value": "from parent cell line U-937", "xref": { "accession": "CVCL_0007", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "U-937", "url": "https://www.cellosaurus.org/CVCL_0007" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:16063", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT10", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16063" }, { "accession": "HGNC:15514", "category": "Organism-specific databases", "database": "HGNC", "label": "PICALM", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15514" } ] }, { "mutation-description": "p.Gly129fs*51 (c.387_388insCGCC)", "mutation-type": "Simple", "source-list": [ { "xref": { "accession": "ACH-002314", "category": "Cell line databases/resources", "database": "DepMap", "url": "https://depmap.org/portal/cell_line/ACH-002314" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:9588", "category": "Organism-specific databases", "database": "HGNC", "label": "PTEN", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9588" } ], "zygosity-type": "Hemizygous" }, { "mutation-description": "p.Gly60Arg (c.178G>C)", "mutation-type": "Simple", "source-list": [ { "xref": { "accession": "ACH-002314", "category": "Cell line databases/resources", "database": "DepMap", "url": "https://depmap.org/portal/cell_line/ACH-002314" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:9644", "category": "Organism-specific databases", "database": "HGNC", "label": "PTPN11", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9644" }, { "accession": "VCV000372590", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000372590" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "c.559+1G>A (p.Val173Trpfs*59)", "mutation-type": "Simple", "source-list": [ { "xref": { "accession": "ACH-002314", "category": "Cell line databases/resources", "database": "DepMap", "url": "https://depmap.org/portal/cell_line/ACH-002314" } } ], "variation-note": "Splice donor mutation", "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" }, { "accession": "VCV000428908", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000428908" } ], "zygosity-type": "Homozygous" }, { "mutation-description": "p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T)", "mutation-type": "Simple", "source-list": [ { "xref": { "accession": "ACH-002314", "category": "Cell line databases/resources", "database": "DepMap", "url": "https://depmap.org/portal/cell_line/ACH-002314" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:12796", "category": "Organism-specific databases", "database": "HGNC", "label": "WT1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12796" }, { "accession": "VCV000449416", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000449416" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "str-list": { "marker-list": [ { "conflict": "false", "id": "Amelogenin", "marker-data-list": [ { "marker-alleles": "X" } ] }, { "conflict": "false", "id": "CSF1PO", "marker-data-list": [ { "marker-alleles": "12" } ] }, { "conflict": "false", "id": "D13S317", "marker-data-list": [ { "marker-alleles": "10,12" } ] }, { "conflict": "false", "id": "D16S539", "marker-data-list": [ { "marker-alleles": "12" } ] }, { "conflict": "false", "id": "D18S51", "marker-data-list": [ { "marker-alleles": "13,14" } ] }, { "conflict": "false", "id": "D19S433", "marker-data-list": [ { "marker-alleles": "14,16" } ] }, { "conflict": "false", "id": "D21S11", "marker-data-list": [ { "marker-alleles": "27,29" } ] }, { "conflict": "false", "id": "D2S1338", "marker-data-list": [ { "marker-alleles": "17,20" } ] }, { "conflict": "false", "id": "D3S1358", "marker-data-list": [ { "marker-alleles": "16" } ] }, { "conflict": "false", "id": "D5S818", "marker-data-list": [ { "marker-alleles": "12" } ] }, { "conflict": "false", "id": "D7S820", "marker-data-list": [ { "marker-alleles": "9,11" } ] }, { "conflict": "false", "id": "D8S1179", "marker-data-list": [ { "marker-alleles": "12,13" } ] }, { "conflict": "false", "id": "FGA", "marker-data-list": [ { "marker-alleles": "21,22,24" } ] }, { "conflict": "false", "id": "Penta D", "marker-data-list": [ { "marker-alleles": "13" } ] }, { "conflict": "false", "id": "Penta E", "marker-data-list": [ { "marker-alleles": "13" } ] }, { "conflict": "false", "id": "TH01", "marker-data-list": [ { "marker-alleles": "6,9.3" } ] }, { "conflict": "false", "id": "TPOX", "marker-data-list": [ { "marker-alleles": "8,11" } ] }, { "conflict": "false", "id": "vWA", "marker-data-list": [ { "marker-alleles": "14,16" } ] } ], "source-list": [ { "xref": { "accession": "909773", "category": "Cell line databases/resources", "database": "Cosmic-CLP", "url": "https://cancer.sanger.ac.uk/cell_lines/sample/overview?id=909773" } }, { "xref": { "accession": "CRL-2367", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/CRL-2367" } } ] }, "web-page-list": [ { "category": "Info", "institution": "-", "specifier": "-", "url": "https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html" } ], "xref-list": [ { "accession": "CLO_0009447", "category": "Cell line databases/resources", "database": "CLO", "iri": "http://purl.obolibrary.org/obo/CLO_0009447", "url": "https://www.ebi.ac.uk/ols4/ontologies/clo/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCLO_0009447" }, { "accession": "E-MTAB-783", "category": "Gene expression databases", "database": "ArrayExpress", "url": "https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-783" }, { "accession": "E-MTAB-3610", "category": "Gene expression databases", "database": "ArrayExpress", "url": "https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-3610" }, { "accession": "CRL-2367", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/CRL-2367" }, { "accession": "SAMN03471833", "category": "Biological sample resources", "database": "BioSample", "url": "https://www.ncbi.nlm.nih.gov/biosample/?term=SAMN03471833" }, { "accession": "CVCL_1775", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_1775" }, { "accession": "SIDM01205", "category": "Cell line databases/resources", "database": "Cell_Model_Passport", "url": "https://cellmodelpassports.sanger.ac.uk/passports/SIDM01205" }, { "accession": "CHEMBL3308519", "category": "Chemistry resources", "database": "ChEMBL-Cells", "url": "https://www.ebi.ac.uk/chembldb/cell/inspect/CHEMBL3308519" }, { "accession": "CHEMBL2366218", "category": "Chemistry resources", "database": "ChEMBL-Targets", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2366218" }, { "accession": "683549", "category": "Polymorphism and mutation databases", "database": "Cosmic", "url": "https://cancer.sanger.ac.uk/cosmic/sample/overview?id=683549" }, { "accession": "909773", "category": "Polymorphism and mutation databases", "database": "Cosmic", "url": "https://cancer.sanger.ac.uk/cosmic/sample/overview?id=909773" }, { "accession": "909773", "category": "Cell line databases/resources", "database": "Cosmic-CLP", "url": "https://cancer.sanger.ac.uk/cell_lines/sample/overview?id=909773" }, { "accession": "ACH-002314", "category": "Cell line databases/resources", "database": "DepMap", "url": "https://depmap.org/portal/cell_line/ACH-002314" }, { "accession": "EGAS00001000978", "category": "Sequence databases", "database": "EGA", "url": "https://ega-archive.org/studies/EGAS00001000978" }, { "accession": "909773", "category": "Chemistry resources", "database": "GDSC", "url": "https://www.cancerrxgene.org/translation/CellLine/909773" }, { "accession": "GSM186464", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM186464" }, { "accession": "GSM1670551", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1670551" }, { "accession": "27263", "category": "Polymorphism and mutation databases", "database": "IARC_TP53" }, { "accession": "LCL-2063", "category": "Cell line databases/resources", "database": "LINCS_LDP", "url": "http://lincsportal.ccs.miami.edu/cells/#/view/LCL-2063" }, { "accession": "TUR_1613_2019", "category": "Chemistry resources", "database": "PharmacoDB", "url": "https://pharmacodb.ca/cell_lines/TUR_1613_2019" }, { "accession": "PXD030304", "category": "Proteomic databases", "database": "PRIDE", "url": "https://www.ebi.ac.uk/pride/archive/projects/PXD030304" }, { "accession": "CVCL_1775", "category": "Polymorphism and mutation databases", "database": "Progenetix", "url": "https://progenetix.org/cellline/?id=cellosaurus:CVCL_1775" }, { "accession": "CVCL_1775", "category": "Chemistry resources", "database": "PubChem_Cell_line", "url": "https://pubchem.ncbi.nlm.nih.gov/cell/CVCL_1775" }, { "accession": "Q54973376", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54973376" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_0007" } ], "age": "37Y", "category": "Cancer cell line", "child-list": [ { "accession": { "type": "primary", "value": "CVCL_F6BN" }, "name": { "type": "identifier", "value": "EDITGENE U-937-CopGFP" } }, { "accession": { "type": "primary", "value": "CVCL_F5U4" }, "name": { "type": "identifier", "value": "EDITGENE U-937-FLUC" } }, { "accession": { "type": "primary", "value": "CVCL_3680" }, "name": { "type": "identifier", "value": "EL 1" } }, { "accession": { "type": "primary", "value": "CVCL_F1UW" }, "name": { "type": "identifier", "value": "HyCyte U-937 KO-hCRBN" } }, { "accession": { "type": "primary", "value": "CVCL_F1UX" }, "name": { "type": "identifier", "value": "HyCyte U-937 KO-hIL1RAP" } }, { "accession": { "type": "primary", "value": "CVCL_E1N8" }, "name": { "type": "identifier", "value": "HyCyte U-937 KO-hPTPRA" } }, { "accession": { "type": "primary", "value": "CVCL_F4MX" }, "name": { "type": "identifier", "value": "HyCyte U-937 stable cell line for hHIF1A overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4M0" }, "name": { "type": "identifier", "value": "HyCyte U-937 stable cell line for hIL1RAP overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_E7RW" }, "name": { "type": "identifier", "value": "iLite Type I IFN Assay Ready Cells" } }, { "accession": { "type": "primary", "value": "CVCL_2082" }, "name": { "type": "identifier", "value": "JOSK-I" } }, { "accession": { "type": "primary", "value": "CVCL_8141" }, "name": { "type": "identifier", "value": "JOSK-K" } }, { "accession": { "type": "primary", "value": "CVCL_2083" }, "name": { "type": "identifier", "value": "JOSK-M" } }, { "accession": { "type": "primary", "value": "CVCL_8142" }, "name": { "type": "identifier", "value": "JOSK-S" } }, { "accession": { "type": "primary", "value": "CVCL_B3XU" }, "name": { "type": "identifier", "value": "MBU-7" } }, { "accession": { "type": "primary", "value": "CVCL_B3XV" }, "name": { "type": "identifier", "value": "MBU-8" } }, { "accession": { "type": "primary", "value": "CVCL_8442" }, "name": { "type": "identifier", "value": "MOBS-1" } }, { "accession": { "type": "primary", "value": "CVCL_L107" }, "name": { "type": "identifier", "value": "PH [Human]" } }, { "accession": { "type": "primary", "value": "CVCL_9997" }, "name": { "type": "identifier", "value": "SAML-1" } }, { "accession": { "type": "primary", "value": "CVCL_6444" }, "name": { "type": "identifier", "value": "SC [Human contaminated U-937]" } }, { "accession": { "type": "primary", "value": "CVCL_1775" }, "name": { "type": "identifier", "value": "TUR" } }, { "accession": { "type": "primary", "value": "CVCL_2810" }, "name": { "type": "identifier", "value": "U-937 cl1-14" } }, { "accession": { "type": "primary", "value": "CVCL_2811" }, "name": { "type": "identifier", "value": "U-937 cl1-22" } }, { "accession": { "type": "primary", "value": "CVCL_8765" }, "name": { "type": "identifier", "value": "U-937 DE-4" } }, { "accession": { "type": "primary", "value": "CVCL_U631" }, "name": { "type": "identifier", "value": "U-937 GTB" } }, { "accession": { "type": "primary", "value": "CVCL_C8E1" }, "name": { "type": "identifier", "value": "U-937 INPP5D KO" } }, { "accession": { "type": "primary", "value": "CVCL_WV56" }, "name": { "type": "identifier", "value": "U-937 RERC" } }, { "accession": { "type": "primary", "value": "CVCL_X000" }, "name": { "type": "identifier", "value": "U-937-AG" } }, { "accession": { "type": "primary", "value": "CVCL_C8Y0" }, "name": { "type": "identifier", "value": "U-937-Luc" } }, { "accession": { "type": "primary", "value": "CVCL_WV55" }, "name": { "type": "identifier", "value": "U-937/CR" } }, { "accession": { "type": "primary", "value": "CVCL_VG84" }, "name": { "type": "identifier", "value": "U-M" } }, { "accession": { "type": "primary", "value": "CVCL_M769" }, "name": { "type": "identifier", "value": "U1/HIV-1" } }, { "accession": { "type": "primary", "value": "CVCL_M770" }, "name": { "type": "identifier", "value": "U38" } }, { "accession": { "type": "primary", "value": "CVCL_8927" }, "name": { "type": "identifier", "value": "U937(CD59+)" } }, { "accession": { "type": "primary", "value": "CVCL_8932" }, "name": { "type": "identifier", "value": "U937(CD59-)" } }, { "accession": { "type": "primary", "value": "CVCL_E9WW" }, "name": { "type": "identifier", "value": "U937(G)" } }, { "accession": { "type": "primary", "value": "CVCL_E9WX" }, "name": { "type": "identifier", "value": "U937(V)" } }, { "accession": { "type": "primary", "value": "CVCL_A5BW" }, "name": { "type": "identifier", "value": "U937-ASPI3K" } }, { "accession": { "type": "primary", "value": "CVCL_2Z95" }, "name": { "type": "identifier", "value": "U937-DC-SIGN" } }, { "accession": { "type": "primary", "value": "CVCL_4V23" }, "name": { "type": "identifier", "value": "U937/ara-C" } }, { "accession": { "type": "primary", "value": "CVCL_Y170" }, "name": { "type": "identifier", "value": "U937/clone21" } }, { "accession": { "type": "primary", "value": "CVCL_Y171" }, "name": { "type": "identifier", "value": "U937/clone36" } }, { "accession": { "type": "primary", "value": "CVCL_Y172" }, "name": { "type": "identifier", "value": "U937/clone41" } }, { "accession": { "type": "primary", "value": "CVCL_Y173" }, "name": { "type": "identifier", "value": "U937/clone49" } }, { "accession": { "type": "primary", "value": "CVCL_A5ZK" }, "name": { "type": "identifier", "value": "U937/EVI1" } }, { "accession": { "type": "primary", "value": "CVCL_X608" }, "name": { "type": "identifier", "value": "U937/HIV-2MS" } }, { "accession": { "type": "primary", "value": "CVCL_Y174" }, "name": { "type": "identifier", "value": "U937/UK110" } }, { "accession": { "type": "primary", "value": "CVCL_Y175" }, "name": { "type": "identifier", "value": "U937/UK711" } }, { "accession": { "type": "primary", "value": "CVCL_8466" }, "name": { "type": "identifier", "value": "YAA" } }, { "accession": { "type": "primary", "value": "CVCL_8467" }, "name": { "type": "identifier", "value": "YAP" } } ], "comment-list": [ { "category": "Anecdotal", "source-list": [ { "reference": { "resource-internal-ref": "DOI=10.1016/j.actaastro.2013.06.007" } }, { "reference": { "resource-internal-ref": "PubMed=10352142" } } ], "value": "Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007)" }, { "category": "Karyotypic information", "value": "Has lost chromosome Y" }, { "category": "Characteristics", "value": "Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA)" }, { "category": "Population", "value": "Caucasian" }, { "category": "Part of", "value": "LL-100 blood cancer cell line panel" }, { "category": "Part of", "value": "Human Protein Atlas, Cell Atlas panel" }, { "category": "Part of", "value": "Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)" }, { "category": "Problematic cell line", "value": "Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937." }, { "category": "Group", "value": "Space-flown cell line (cellonaut)" } ], "created": "2012-04-04", "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Pleural effusion", "xref-list": [ { "accession": "UBERON_0000175", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000175", "label": "pleural effusion", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000175" } ] } } ], "disease-list": [ { "accession": "C8263", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C8263", "label": "Adult acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8263" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": 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