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"CVCL_E8DQ" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 B2M KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DR" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 B2M/CIITA dKO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DS" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 CD36 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DT" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 CIITA KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DU" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 FCGR1A KO" } }, { "accession": { "type": "primary", "value": "CVCL_F0PJ" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 ISRE-driven luciferase reporter" } }, { "accession": { "type": "primary", "value": "CVCL_KB46" }, "name": { "type": "identifier", "value": "CellSensor NFkB-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_KS29" }, "name": { "type": "identifier", "value": "CellSensor SIE-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_KS30" }, "name": { "type": "identifier", "value": "CellSensor TNFalpha-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_F6J1" }, "name": { "type": "identifier", "value": "EDITGENE CD63 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F5BW" }, "name": { "type": "identifier", "value": "EDITGENE IL4I1 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F5Q8" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-Cas9" } }, { "accession": { "type": "primary", "value": "CVCL_F6A1" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-CopGFP" } }, { "accession": { "type": "primary", "value": "CVCL_F5SJ" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-FLUC" } }, { "accession": { "type": "primary", "value": "CVCL_F6JI" }, "name": { "type": "identifier", "value": "EDITGENE TLR7 and TLR8 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F4KS" }, "name": { "type": "identifier", "value": "HyCyte CT26 mKRAS_p.G12C_c.557G\uff1eT cell line" } }, { "accession": { "type": "primary", "value": "CVCL_F4KT" }, "name": { "type": "identifier", "value": "HyCyte CT26 mKRAS_p.G12C_c.558G\uff1eT cell line" } }, { "accession": { "type": "primary", "value": "CVCL_E2QA" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hADAP1_p.P14R_c.41C>G" } }, { "accession": { "type": "primary", "value": "CVCL_F4K8" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hIRF8_c.1278/insT/c.1279 cell line" } }, { "accession": { "type": "primary", "value": "CVCL_E2QB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hKDM6A_p.A694T_c.2080G>A" } }, { "accession": { "type": "primary", "value": "CVCL_F4KL" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hLACC1_p.V254I_c.760G\uff1eA cell line" } }, { "accession": { "type": "primary", "value": "CVCL_F1TU" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hACSL4" } }, { "accession": { "type": "primary", "value": "CVCL_F4GH" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hAIM2" } }, { "accession": { "type": "primary", "value": "CVCL_D6CN" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCASP1" } }, { "accession": { "type": "primary", "value": "CVCL_F1TV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD22" } }, { "accession": { "type": "primary", "value": "CVCL_D6CP" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD274" } }, { "accession": { "type": "primary", "value": "CVCL_F1TW" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD33" } }, { "accession": { "type": "primary", "value": "CVCL_D6CQ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD44" } }, { "accession": { "type": "primary", "value": "CVCL_F1TX" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCEBPB" } }, { "accession": { "type": "primary", "value": "CVCL_F1TY" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCGAS" } }, { "accession": { "type": "primary", "value": "CVCL_F4FR" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCNDP2" } }, { "accession": { "type": "primary", "value": "CVCL_F4F3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCYBB" } }, { "accession": { "type": "primary", "value": "CVCL_F1TZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hDAPP1" } }, { "accession": { "type": "primary", "value": "CVCL_F4JG" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hDNASE2" } }, { "accession": { "type": "primary", "value": "CVCL_E1MY" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hELF4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U0" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hFPR2" } }, { "accession": { "type": "primary", "value": "CVCL_F4IQ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGPI" } }, { "accession": { "type": "primary", "value": "CVCL_F1U1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGPR39" } }, { "accession": { "type": "primary", "value": "CVCL_E1MZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGSDMD" } }, { "accession": { "type": "primary", "value": "CVCL_F1U2" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGSDME" } }, { "accession": { "type": "primary", "value": "CVCL_E1N0" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hHNRNPA2B1" } }, { "accession": { "type": "primary", "value": "CVCL_F1U3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIFI27" } }, { "accession": { "type": "primary", "value": "CVCL_F1U4" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIL6R" } }, { "accession": { "type": "primary", "value": "CVCL_E1N1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIRAK4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U5" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hITGAM" } }, { "accession": { "type": "primary", "value": "CVCL_F4FB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIVNS1ABP" } }, { "accession": { "type": "primary", "value": "CVCL_E1N2" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hLAMTOR2" } }, { "accession": { "type": "primary", "value": "CVCL_F1U6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hLINC01355" } }, { "accession": { "type": "primary", "value": "CVCL_E1N3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMCFD2" } }, { "accession": { "type": "primary", "value": "CVCL_F1U7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMLKL" } }, { "accession": { "type": "primary", "value": "CVCL_F4H1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMT1G" } }, { "accession": { "type": "primary", "value": "CVCL_F4J7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hN4BP3" } }, { "accession": { "type": "primary", "value": "CVCL_E1N4" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNCF1" } }, { "accession": { "type": "primary", "value": "CVCL_F4GC" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNEDD4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U8" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNR1H3" } }, { "accession": { "type": "primary", "value": "CVCL_F1U9" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNSUN3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UA" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hOASL" } }, { "accession": { "type": "primary", "value": "CVCL_E1N5" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hOSM" } }, { "accession": { "type": "primary", "value": "CVCL_F1UB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPGAM5" } }, { "accession": { "type": "primary", "value": "CVCL_F4HL" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPI4KA" } }, { "accession": { "type": "primary", "value": "CVCL_F1UC" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPLD3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UD" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPYCARD" } }, { "accession": { "type": "primary", "value": "CVCL_F1UE" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSERPINB3" } }, { "accession": { "type": "primary", "value": "CVCL_E1N6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSETDB2" } }, { "accession": { "type": "primary", "value": "CVCL_F4GV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSIRPA" } }, { "accession": { "type": "primary", "value": "CVCL_E1N7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSMAD3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UF" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTARM1" } }, { "accession": { "type": "primary", "value": "CVCL_F1UG" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTBK1" } }, { "accession": { "type": "primary", "value": "CVCL_F1UH" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTGFBR1" } }, { "accession": { "type": "primary", "value": "CVCL_D6CR" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTHRAP3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UI" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTLR4" } }, { "accession": { "type": "primary", "value": "CVCL_D6CS" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTNF" } }, { "accession": { "type": "primary", "value": "CVCL_F4HZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTRAF2 and hTRAF2" } }, { "accession": { "type": "primary", "value": "CVCL_D6CT" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hUSP10" } }, { "accession": { "type": "primary", "value": "CVCL_F1UJ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hVCPIP1" } }, { "accession": { "type": "primary", "value": "CVCL_F4SV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hCHRM3 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4NX" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hDAPP1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4PK" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hNR1H3 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4R9" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hPDHA1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4T6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hSTING1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4MS" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hSYVN1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_E3IS" }, "name": { "type": "identifier", "value": "HyCyte THP-1-Luc" } }, { "accession": { "type": "primary", "value": "CVCL_KZ70" }, "name": { "type": "identifier", "value": "PathHunter THP-1 IkappaB Degradation" } }, { "accession": { "type": "primary", "value": "CVCL_IR08" }, "name": { "type": "identifier", "value": "PSC-THP1" } }, { "accession": { "type": "primary", "value": "CVCL_A4CA" }, "name": { "type": "identifier", "value": "THP-1 AP1-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_A4CB" }, "name": { "type": "identifier", "value": "THP-1 CRE-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_A4CD" }, "name": { "type": "identifier", "value": "THP-1 GAS-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_E7CQ" }, "name": { "type": "identifier", "value": "THP-1 IQAD biosensor" } }, { "accession": { "type": "primary", "value": "CVCL_A4CC" }, "name": { "type": "identifier", "value": "THP-1 ISRE-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_F1K5" }, "name": { "type": "identifier", "value": "THP-1 K5 P/A" } }, { "accession": { "type": "primary", "value": "CVCL_F1K6" }, "name": { "type": "identifier", "value": "THP-1 K5 WT" } }, { "accession": { "type": "primary", "value": "CVCL_F1K7" }, "name": { "type": "identifier", "value": "THP-1 K5 Y/A" } }, { "accession": { "type": "primary", "value": "CVCL_E2QQ" }, "name": { "type": "identifier", "value": "THP-1 NF-kappaB-eGFP" } }, { "accession": { "type": "primary", "value": "CVCL_A4CE" }, "name": { "type": "identifier", "value": "THP-1 NF-kB-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_XZ65" }, "name": { "type": "identifier", "value": "THP-1 NF-kb-Luc2 reporter" } }, { "accession": { "type": "primary", "value": "CVCL_B5NS" }, "name": { "type": "identifier", "value": "THP-1 NFAT-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_DF52" }, "name": { "type": "identifier", "value": "THP-1 NucLight Red" } }, { "accession": { "type": "primary", "value": "CVCL_E7B2" }, "name": { "type": "identifier", "value": "THP-1 PSMB9-eGFP-His" } }, { "accession": { "type": "primary", "value": "CVCL_C3EW" }, "name": { "type": "identifier", "value": "THP-1 Safe Harbor Landing Pad" } }, { "accession": { "type": "primary", "value": "CVCL_XI47" }, "name": { "type": "identifier", "value": "THP-1 TLR9 mCherry" } }, { "accession": { "type": "primary", "value": "CVCL_0R25" }, "name": { "type": "identifier", "value": "THP-1(NCI)" } }, { "accession": { "type": "primary", "value": "CVCL_C0YT" }, "name": { "type": "identifier", "value": "THP-1-Cs5" } }, { "accession": { "type": "primary", "value": "CVCL_C8WG" }, "name": { "type": "identifier", "value": "THP-1-EGFP" } }, { "accession": { "type": "primary", "value": "CVCL_C8WH" }, "name": { "type": "identifier", "value": "THP-1-Luc" } }, { "accession": { "type": "primary", "value": "CVCL_C0YQ" }, "name": { "type": "identifier", "value": "THP-1-R" } }, { "accession": { "type": "primary", "value": "CVCL_WI26" }, "name": { "type": "identifier", "value": "THP-1/AR" } }, { "accession": { "type": "primary", "value": "CVCL_4V22" }, "name": { "type": "identifier", "value": "THP-1/ara-C" } }, { "accession": { "type": "primary", "value": "CVCL_0R21" }, "name": { "type": "identifier", "value": "THP-1/DC-SIGN" } }, { "accession": { "type": "primary", "value": "CVCL_A1RT" }, "name": { "type": "identifier", "value": "THP-1/E" } }, { "accession": { "type": "primary", "value": "CVCL_XD94" }, "name": { "type": "identifier", "value": "THP-1/IL15" } }, { "accession": { "type": "primary", "value": "CVCL_XD95" }, "name": { "type": "identifier", "value": "THP-1/IL21" } }, { "accession": { "type": "primary", "value": "CVCL_3426" }, "name": { "type": "identifier", "value": "THP-1h" } }, { "accession": { "type": "primary", "value": "CVCL_3427" }, "name": { "type": "identifier", "value": "THP-1l" } }, { "accession": { "type": "primary", "value": "CVCL_D5JL" }, "name": { "type": "identifier", "value": "THP-G1b" } }, { "accession": { "type": "primary", "value": "CVCL_D5JK" }, "name": { "type": "identifier", "value": "THP-G8" } }, { "accession": { "type": "primary", "value": "CVCL_C0QX" }, "name": { "type": "identifier", "value": "THP1 GFP-PEAK3" } }, { "accession": { "type": "primary", "value": "CVCL_C0QY" }, "name": { "type": "identifier", "value": "THP1 ST-PEAK3" } }, { "accession": { "type": "primary", "value": "CVCL_A8AT" }, "name": { "type": "identifier", "value": "THP1-ASC-GFP" } }, { "accession": { "type": "primary", "value": "CVCL_X588" }, "name": { "type": "identifier", "value": "THP1-Blue ISG" } }, { "accession": { "type": "primary", "value": "CVCL_X589" }, "name": { "type": "identifier", "value": "THP1-Blue ISG-KD-STING" } }, { "accession": { "type": "primary", "value": "CVCL_X585" }, "name": { "type": "identifier", "value": "THP1-Blue NF-kappaB" } }, { "accession": { "type": "primary", "value": "CVCL_E8F3" }, "name": { "type": "identifier", "value": "THP1-Blue NF-kappaB v2" } }, { "accession": { "type": "primary", "value": "CVCL_X599" }, "name": { "type": "identifier", "value": "THP1-Dual" } }, { "accession": { "type": "primary", "value": "CVCL_A8BE" }, "name": { "type": "identifier", "value": "THP1-HMGB1-Lucia" } }, { "accession": { "type": "primary", "value": "CVCL_X587" }, "name": { "type": "identifier", "value": "THP1-Lucia ISG" } }, { "accession": { "type": "primary", "value": "CVCL_X590" }, "name": { "type": "identifier", "value": "THP1-Lucia NF-kappaB" } }, { "accession": { "type": "primary", "value": "CVCL_E8F9" }, "name": { "type": "identifier", "value": "THP1-Lucia NF-kappaB v2" } }, { "accession": { "type": "primary", "value": "CVCL_5I77" }, "name": { "type": "identifier", "value": "THP1-NLRC4" } }, { "accession": { "type": "primary", "value": "CVCL_X601" }, "name": { "type": "identifier", "value": "THP1-Null" } }, { "accession": { "type": "primary", "value": "CVCL_A8AK" }, "name": { "type": "identifier", "value": "THP1-Null2" } }, { "accession": { "type": "primary", "value": "CVCL_X582" }, "name": { "type": "identifier", "value": "THP1-XBlue" } }, { "accession": { "type": "primary", "value": "CVCL_A0HA" }, "name": { "type": "identifier", "value": "THP18" } }, { "accession": { "type": "primary", "value": "CVCL_E1CM" }, "name": { "type": "identifier", "value": "Ubigene THP-1 ACOD1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CN" }, "name": { "type": "identifier", "value": "Ubigene THP-1 ADA2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CP" }, "name": { "type": "identifier", "value": "Ubigene THP-1 AHR KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CQ" }, "name": { "type": "identifier", "value": "Ubigene THP-1 C15orf48 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CR" }, "name": { "type": "identifier", "value": "Ubigene THP-1 CARD8 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CS" }, "name": { "type": "identifier", "value": "Ubigene THP-1 CES1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CT" }, "name": { "type": "identifier", "value": "Ubigene THP-1 CLEC10A KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CU" }, "name": { "type": "identifier", "value": "Ubigene THP-1 CLEC4A KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CV" }, "name": { "type": "identifier", "value": "Ubigene THP-1 EGR1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CW" }, "name": { "type": "identifier", "value": "Ubigene THP-1 GLP1R KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CX" }, "name": { "type": "identifier", "value": "Ubigene THP-1 GPNMB KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CY" }, "name": { "type": "identifier", "value": "Ubigene THP-1 GSDMD KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1CZ" }, "name": { "type": "identifier", "value": "Ubigene THP-1 HERC5 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D0" }, "name": { "type": "identifier", "value": "Ubigene THP-1 IFI35 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D1" }, "name": { "type": "identifier", "value": "Ubigene THP-1 ISG15 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D2" }, "name": { "type": "identifier", "value": "Ubigene THP-1 MCU KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D3" }, "name": { "type": "identifier", "value": "Ubigene THP-1 MILR1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D4" }, "name": { "type": "identifier", "value": "Ubigene THP-1 NFE2L2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D5" }, "name": { "type": "identifier", "value": "Ubigene THP-1 NLRP3 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E1D6" }, "name": { "type": "identifier", "value": "Ubigene THP-1 NMI KO" } }, { "accession": { "type": 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"https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], 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], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "doubling-time-list": [ { "doubling-time-value": "24-48 hours", "source-list": [ { "xref": { "accession": "CGKO-M2174", "category": "Cell line collections (Providers)", "database": "Hysigen", "url": "https://hysigen.com/CGKO-M2174.html" } } ] } ], "doubling-time-range": { "max": "48", "min": "24", "unit": "hour" }, "entry-version": "2", "last-updated": "2024-12-19", "name-list": [ { "type": "identifier", "value": "HyCyte THP-1 hKDM6A_p.A694T_c.2080G>A" }, { "type": "synonym", "value": "hKDM6A_p.A694T_c.2080G>A THP-1" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Ala746Thr (c.2080G>A)", "mutation-type": "Simple_edited", "source-list": [ { "xref": { "accession": "CGMU-M2174", "category": "Cell line collections (Providers)", "database": "Hysigen", "url": "https://hysigen.com/CGMU-M2174.html" } } ], "variation-note": "By CRISPR/Cas9", "variation-type": "Mutation", "xref-list": [ { "accession": "VGNC:54168", "category": 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"doubling-time-list": [ { "doubling-time-value": "~48 hours", "source-list": [ { "xref": { "accession": "KC-1216", "category": "Cell line collections (Providers)", "database": "KYinno", "url": "https://www.kyinno.com/?s=KC-1216" } } ] } ], "doubling-time-range": { "max": "48", "min": "48", "unit": "hour" }, "entry-version": "13", "genetic-integration-list": [ { "genetic-integration-note": "With optimized codon usage for mammalian expression = Luc2", "method": "Transduction", "xref": { "accession": "P08659", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P08659", "label": "Photinus pyralis firefly-type luciferase", "url": "https://www.uniprot.org/uniprotkb/P08659/entry" } }, { "method": "Transduction", "xref": { "accession": "P00557", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P00557", "label": "Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR)", "url": 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"mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_XZ65", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_XZ65" }, { "accession": "KC-1216", "category": "Cell line collections (Providers)", "database": "KYinno", "discontinued": "true" }, { "accession": "Q98133244", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q98133244" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_C3EW" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "CLL1223", "category": "Cell line collections (Providers)", "database": "Sigma-Aldrich", "url": "https://www.sigmaaldrich.com/catalog/product/sigma/CLL1223" } } ], "value": "Using ZFN a fluorescent mKATE2 tag flanked by Cre-lox sites (LoxN-EF1a-Lox2272-mKATE2-LoxP) was introduced in the AAVS1 safe harbor locus. The mKATE2 tag can be exchanged for a payload of the user's choice using Cre recombinase and a targeting vector with appropriate lox sites (Sigma-Aldrich=CLL1223)" }, { "category": "Population", "value": "Japanese" } ], "created": "2022-09-22", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "doubling-time-list": [ { "doubling-time-value": "~24 hours", "source-list": [ { "institution": "Sigma-Aldrich", "value": "Sigma-Aldrich" } ] } ], "doubling-time-range": { "max": "24", "min": "24", "unit": "hour" }, "entry-version": "7", "genetic-integration-list": [ { "genetic-integration-note": "Bright red fluorescent protein derived from eqFP578", "method": "ZFN", "xref": { "accession": "DBBO8", "category": "Sequence databases", "database": "FPbase", "label": "mKate2", "url": "https://www.fpbase.org/protein/DBBO8/" } } ], "last-updated": "2024-12-19", 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