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"accession-list": [ { "type": "primary", "value": "CVCL_B5NS" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "TIB-202-NFAT-LUC2", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/TIB-202-NFAT-LUC2" } } ], "value": "Stably expresses firefly luciferase under the control of the NFAT response element (ATCC=TIB-202-NFAT-LUC2)" }, { "category": "Population", "value": "Japanese" } ], "created": "2023-10-05", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "doubling-time-list": [ { "doubling-time-value": "~72 hours", "source-list": [ { "xref": { "accession": "TIB-202-NFAT-LUC2", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/TIB-202-NFAT-LUC2" } } ] } ], "doubling-time-range": { "max": "72", "min": "72", "unit": "hour" }, "entry-version": "6", "genetic-integration-list": [ { "method": "Transduction", "xref": { "accession": "P13249", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P13249", "label": "Streptomyces alboniger pac (PuroR)", "url": "https://www.uniprot.org/uniprotkb/P13249/entry" } }, { "genetic-integration-note": "With optimized codon usage for mammalian expression = Luc2", "method": "Transduction", "xref": { "accession": "P08659", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P08659", "label": "Photinus pyralis firefly-type luciferase", "url": "https://www.uniprot.org/uniprotkb/P08659/entry" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP-1 NFAT-Luc2" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "str-list": { "marker-list": [ { "conflict": "false", "id": "Amelogenin", "marker-data-list": [ { "marker-alleles": "X,Y" } ] }, { "conflict": "false", "id": "CSF1PO", "marker-data-list": [ { "marker-alleles": "11,13" } ] }, { "conflict": "false", "id": "D13S317", "marker-data-list": [ { "marker-alleles": "13" } ] }, { "conflict": "false", "id": "D16S539", "marker-data-list": [ { "marker-alleles": "11,12" } ] }, { "conflict": "false", "id": "D5S818", "marker-data-list": [ { "marker-alleles": "11,12" } ] }, { "conflict": "false", "id": "D7S820", "marker-data-list": [ { "marker-alleles": "10" } ] }, { "conflict": "false", "id": "TH01", "marker-data-list": [ { "marker-alleles": "8,9.3" } ] }, { "conflict": "false", "id": "TPOX", "marker-data-list": [ { "marker-alleles": "8,11" } ] }, { "conflict": "false", "id": "vWA", "marker-data-list": [ { "marker-alleles": "16" } ] } ], "source-list": [ { "xref": { "accession": "TIB-202-NFAT-LUC2", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/TIB-202-NFAT-LUC2" } } ] }, "xref-list": [ { "accession": "TIB-202-NFAT-LUC2", "category": "Cell line collections (Providers)", "database": "ATCC", "url": "https://www.atcc.org/products/TIB-202-NFAT-LUC2" }, { "accession": "Q123033609", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q123033609" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_C3EW" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "CLL1223", "category": "Cell line collections (Providers)", "database": "Sigma-Aldrich", "url": "https://www.sigmaaldrich.com/catalog/product/sigma/CLL1223" } } ], "value": "Using ZFN a fluorescent mKATE2 tag flanked by Cre-lox sites (LoxN-EF1a-Lox2272-mKATE2-LoxP) was introduced in the AAVS1 safe harbor locus. The mKATE2 tag can be exchanged for a payload of the user's choice using Cre recombinase and a targeting vector with appropriate lox sites (Sigma-Aldrich=CLL1223)" }, { "category": "Population", "value": "Japanese" } ], "created": "2022-09-22", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "doubling-time-list": [ { "doubling-time-value": "~24 hours", "source-list": [ { "institution": "Sigma-Aldrich", "value": "Sigma-Aldrich" } ] } ], "doubling-time-range": { "max": "24", "min": "24", "unit": "hour" }, "entry-version": "7", "genetic-integration-list": [ { "genetic-integration-note": "Bright red fluorescent protein derived from eqFP578", "method": "ZFN", "xref": { "accession": "DBBO8", "category": "Sequence databases", "database": "FPbase", "label": "mKate2", "url": "https://www.fpbase.org/protein/DBBO8/" } } ], "last-updated": "2024-12-19", "name-list": [ { "type": "identifier", "value": "THP-1 Safe Harbor Landing Pad" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_C3EW", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_C3EW" }, { "accession": "CLL1223", "category": "Cell line collections (Providers)", "database": "Sigma-Aldrich", "url": "https://www.sigmaaldrich.com/catalog/product/sigma/CLL1223" }, { "accession": "Q114313119", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q114313119" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_X589" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thp-kdstg", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thp-kdstg" } } ], "value": "SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an ISG54 promoter enhanced by a multimeric ISRE (InvivoGen=thp-kdstg)" }, { "category": "Population", "value": "Japanese" } ], "created": "2014-09-05", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "19", "genetic-integration-list": [ { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "shRNA knockdown", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-04-10", "name-list": [ { "type": "identifier", "value": "THP1-Blue ISG-KD-STING" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": 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"category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:7562", "category": "Organism-specific databases", "database": "HGNC", "label": "MYD88", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7562" } } ], "last-updated": "2025-04-10", "name-list": [ { "type": "identifier", "value": "THP1-XBlue-defMyD" }, { "type": "synonym", "value": "MyD88-/- THP-1" } ], "reference-list": [ { "resource-internal-ref": "PubMed=25130606" } ], "sequence-variation-list": [ { "mutation-description": 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"NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "web-page-list": [ { "category": "Provider", "institution": "InvivoGen", "specifier": "thpx-dmyd", "url": "https://web.archive.org/web/20170705151443/http://www.invivogen.com/thp1-xblue-defmyd-cell" } ], "xref-list": [ { "accession": "CVCL_X586", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_X586" }, { "accession": "thpx-dmyd", "category": "Cell line collections (Providers)", "database": "InvivoGen", "discontinued": "true" }, { "accession": "Q54972377", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54972377" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_SU97" } ], "age": "40Y", "category": "Cancer cell line", "child-list": 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"accession": "HZGHC001319c008", "category": "Cell line collections (Providers)", "database": "Horizon_Discovery", "url": "https://horizondiscovery.com/en/search?searchterm=HZGHC001319c008" }, { "accession": "PXD010335", "category": "Proteomic databases", "database": "PRIDE", "url": "https://www.ebi.ac.uk/pride/archive/projects/PXD010335" }, { "accession": "Q54876005", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54876005" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_SU98" } ], "age": "40Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Group", "value": "Haploid karyotype cell line" } ], "created": "2018-05-14", "derived-from": [ { "accession": "CVCL_Y019", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HAP1", "url": "https://www.cellosaurus.org/CVCL_Y019" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Bone 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"age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "value": "PathHunter degradation cell lines express a target protein tagged with a beta-galactosidase fragment (Enzyme Donor=ED). Pathway activation results in the degradation of the target protein. The degraded protein is detected by adding to the cell lysis buffer another beta-galactosidase fragment (Enzyme Acceptor=EA). 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"xref-list": [ { "accession": "CVCL_KZ70", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_KZ70" }, { "accession": "93-0538C14", "category": "Cell line collections (Providers)", "database": "DiscoverX", "url": "https://emea.discoverx.com/catalog/93-0538C14" }, { "accession": "Q54938064", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54938064" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AT" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thp-ascgfp", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thp-ascgfp" } } ], "value": "Stably expresses a PYCARD-GFP construct under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB 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The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thp-ascgfp)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": 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"category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ 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"database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117039" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BE" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thp1-gb1lc", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thp1-gb1lc" } } ], "value": "Designed to monitor ferroptosis, a form of non-apoptotic cell death. Stably express an HMGB1::Lucia luciferase fusion protein in the cytoplasm, following ferroptosis activation, the cell membrane ruptures and HMGB1::Lucia is released in the extracellular milieu (InvivoGen=thp1-gb1lc)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "10", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:4983", "category": "Organism-specific databases", "database": "HGNC", "label": "HMGB1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4983" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-HMGB1-Lucia" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": 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"variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BE", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BE" }, { "accession": "thp-gb1lc", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thp-gb1lc" }, { "accession": "Q107117083", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117083" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_X584" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpx-mdcdsp", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpx-mdcdsp" } } ], "value": "SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter (InvivoGen=thpx-mdcdsp)" }, { "category": "Population", "value": "Japanese" } ], "created": "2014-09-05", "derived-from": [ { "accession": "CVCL_X582", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-XBlue", "url": "https://www.cellosaurus.org/CVCL_X582" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": 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"category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P00552", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P00552", "label": "Klebsiella pneumoniae transposon Tn5 neo", "url": "https://www.uniprot.org/uniprotkb/P00552/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:17156", "category": "Organism-specific databases", "database": "HGNC", "label": "LY96", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17156" } }, { "method": "Transfection", "xref": { "accession": "HGNC:1628", "category": "Organism-specific databases", "database": "HGNC", "label": "CD14", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1628" } }, { "method": "Transfection", 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"accession": { "type": "primary", "value": "CVCL_A8BA" }, "name": { "type": "identifier", "value": "THP1-Dual KO-MAVS" } }, { "accession": { "type": "primary", "value": "CVCL_A8BB" }, "name": { "type": "identifier", "value": "THP1-Dual KO-MDA5" } }, { "accession": { "type": "primary", "value": "CVCL_5J54" }, "name": { "type": "identifier", "value": "THP1-Dual KO-MyD" } }, { "accession": { "type": "primary", "value": "CVCL_A8BC" }, "name": { "type": "identifier", "value": "THP1-Dual KO-RIG-I" } }, { "accession": { "type": "primary", "value": "CVCL_E8F8" }, "name": { "type": "identifier", "value": "THP1-Dual KO-SAMHD1" } }, { "accession": { "type": "primary", "value": "CVCL_A8AH" }, "name": { "type": "identifier", "value": "THP1-Dual KO-STING" } }, { "accession": { "type": "primary", "value": "CVCL_A8AY" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TBK1" } }, { "accession": { "type": "primary", "value": "CVCL_A8AW" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TLR2" } }, { "accession": { "type": "primary", "value": "CVCL_A8AX" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TLR4" } }, { "accession": { "type": "primary", "value": "CVCL_A8BW" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TLR8" } }, { "accession": { "type": "primary", "value": "CVCL_A8AJ" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TREX1" } }, { "accession": { "type": "primary", "value": "CVCL_A8AM" }, "name": { "type": "identifier", "value": "THP1-Dual KO-TRIF" } }, { "accession": { "type": "primary", "value": "CVCL_E8FF" }, "name": { "type": "identifier", "value": "THP1-Dual MD2-CD14 KO-TLR4" } }, { "accession": { "type": "primary", "value": "CVCL_E8FE" }, "name": { "type": "identifier", "value": "THP1-Dual MD2-CD14-TLR4" } } ], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-nfis", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-nfis" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-nfis)" }, { "category": "Population", "value": "Japanese" } ], "created": "2014-09-05", "derived-from": [ { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": 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"https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Gene fusion", "xref-list": [ 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databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP-1", "xref": { "accession": "CVCL_0006", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP-1", "url": "https://www.cellosaurus.org/CVCL_0006" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_X599" }, { "accession": "thpd-nfis", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-nfis" }, { "accession": "Q54972368", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54972368" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_V162" } ], "age": "Blastocyst stage", "category": "Embryonic stem cell", "cell-type": { "value": "Embryonic stem cell", "xref": { "accession": "CL_0002322", "category": "Anatomy/cell type resources", "database": "CL", "iri": "http://purl.obolibrary.org/obo/CL_0002322", "label": "embryonic stem cell", "url": "https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0002322" } }, "child-list": [], "comment-list": [ { "category": "Karyotypic information", "source-list": [ { "institution": "BNLC", "value": "BNLC" } ], "value": "46,XY,+i(7)p(11),-7 (BNLC)" }, { "category": "Characteristics", "value": "Transduced with a pRRL-EF1a-MLLAF4-PGKp-Neo construct" }, { "category": "From", "value": "Centre for Genomics and Oncological Research (GENYO); Granada; Spain" }, { "category": "Part of", "value": "Spanish Stem Cell Bank (Banco Nacional de Lineas Celulares) collection" } ], "created": "2014-04-16", "derived-from": [ { "accession": "CVCL_B526", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "AND-1", "url": "https://www.cellosaurus.org/CVCL_B526" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Blastocyst", "xref-list": [ { "accession": "UBERON_0000358", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000358", "label": "blastocyst", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000358" } ] } } ], "entry-version": "14", "genetic-integration-list": [ { "method": "Transduction", "xref": { "accession": "P00552", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P00552", "label": "Klebsiella pneumoniae transposon Tn5 neo", "url": "https://www.uniprot.org/uniprotkb/P00552/entry" } }, { "genetic-integration-note": "KMT2-AFF1/MLL-AF4 fusion", "method": "Transduction", "xref": { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" } }, { "genetic-integration-note": "KMT2-AFF1/MLL-AF4 fusion", "method": "Transduction", "xref": { "accession": "HGNC:7135", "category": "Organism-specific databases", "database": "HGNC", "label": "AFF1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7135" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "AND-1 MLLAF4" }, { "type": "synonym", "value": "AND-1-MLLAF4" }, { "type": 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resources", "database": "PubChem_Cell_line", "url": "https://pubchem.ncbi.nlm.nih.gov/cell/CVCL_0093" }, { "accession": "Q54951304", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54951304" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8CC" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpb-ip10kilc", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpb-ip10kilc" } } ], "value": "SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 copies of the NF-kappaB consensus TRE and 3 copies of the c-Rel binding site (InvivoGen=thpb-ip10kilc)" }, { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpb-ip10kilc", "category": "Cell line 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"https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } }, { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Homologous recombination", "value": "Synthetic construct Lucia luciferase" } ], "knockout-cell-list": [ { "method": "Homologous recombination", "xref": { "accession": "HGNC:10637", "category": "Organism-specific databases", "database": "HGNC", "label": "CXCL10", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10637" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Blue KI-IP10" }, { "type": "synonym", "value": "THP1-Blue KI-IP10-Lucia" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", 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"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Blue NF-kappaB", "xref": { "accession": "CVCL_X585", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Blue NF-kappaB", "url": "https://www.cellosaurus.org/CVCL_X585" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8CC", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8CC" }, { "accession": "thpb-ip10kilc", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpb-ip10kilc" }, { "accession": "Q107117042", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117042" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FA" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-htlr3", "category": "Cell line collections 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THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-htlr3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr3" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FB" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-htlr7", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr7" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-htlr7)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:15631", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR7", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15631" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual hTLR7" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-htlr7", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr7" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FC" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-htlr8", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr8" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-htlr8)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:15632", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR8", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15632" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual hTLR8" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-htlr8", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr8" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FD" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-htlr9", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr9" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-htlr9)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P13249", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P13249", "label": "Streptomyces alboniger pac (PuroR)", "url": "https://www.uniprot.org/uniprotkb/P13249/entry" } }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:15633", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR9", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15633" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual hTLR9" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-htlr9", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-htlr9" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BI" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-r232", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-r232" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-r232)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KI-hSTING-R232" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific 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"primary", "value": "CVCL_A8BD" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-mstg", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-mstg" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-mstg)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": 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"KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific 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"primary", "value": "CVCL_A8AI" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kocgas", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kocgas" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kocgas)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:21367", "category": "Organism-specific databases", "database": "HGNC", "label": "CGAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21367" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-cGAS" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AI", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AI" }, { "accession": "thpd-kocgas", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kocgas" }, { "accession": "Q107117056", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117056" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8F4" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kodnase2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kodnase2" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kodnase2)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:2960", "category": "Organism-specific databases", "database": "HGNC", "label": "DNASE2", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2960" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-DNase2" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-kodnase2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kodnase2" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AU" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koifi16", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koifi16" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koifi16)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:5395", "category": "Organism-specific databases", "database": "HGNC", "label": "IFI16", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5395" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IFI16" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AU", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AU" }, { "accession": "thpd-koifi16", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koifi16" }, { "accession": "Q107117058", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117058" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AL" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koifnar2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koifnar2" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koifnar2)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:5433", "category": "Organism-specific databases", "database": "HGNC", "label": "IFNAR2", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5433" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IFNAR2" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AL", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AL" }, { "accession": "thpd-koifnar2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koifnar2" }, { "accession": "Q107117059", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117059" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AZ" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koikke", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koikke" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koikke)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:14552", "category": "Organism-specific databases", "database": "HGNC", "label": "IKBKE", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14552" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IKKepsilon" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AZ", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AZ" }, { "accession": "thpd-koikke", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koikke" }, { "accession": "Q107117061", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117061" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8F5" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koirf1", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf1" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koirf1)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:6116", "category": "Organism-specific databases", "database": "HGNC", "label": "IRF1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6116" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IRF1" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-koirf1", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf1" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AV" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koirf3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf3" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koirf3)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:6118", "category": "Organism-specific databases", "database": "HGNC", "label": "IRF3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6118" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IRF3" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AV", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AV" }, { "accession": "thpd-koirf3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf3" }, { "accession": "Q107117063", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117063" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8F6" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koirf5", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf5" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koirf5)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:6120", "category": "Organism-specific databases", "database": "HGNC", "label": "IRF5", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6120" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IRF5" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-koirf5", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf5" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8F7" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-koirf7", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf7" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-koirf7)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:6122", "category": "Organism-specific databases", "database": "HGNC", "label": "IRF7", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6122" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-IRF7" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-koirf7", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-koirf7" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BA" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-komavs", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komavs" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-komavs)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:29233", "category": "Organism-specific databases", "database": "HGNC", "label": "MAVS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29233" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-MAVS" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BA", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BA" }, { "accession": "thpd-komavs", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komavs" }, { "accession": "Q107117065", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117065" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BB" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-komda5", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komda5" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-komda5)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:18873", "category": "Organism-specific databases", "database": "HGNC", "label": "IFIH1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18873" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-MDA5" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BB", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BB" }, { "accession": "thpd-komda5", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komda5" }, { "accession": "Q107117066", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117066" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_5J54" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-komyd", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komyd" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-komyd)" }, { "category": "Population", "value": "Japanese" } ], "created": "2015-12-14", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "19", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:7562", "category": "Organism-specific databases", "database": "HGNC", "label": "MYD88", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7562" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-MyD" }, { "type": "synonym", "value": "THP1-Dual KO-MyD88" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_5J54", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_5J54" }, { "accession": "thpd-komyd", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-komyd" }, { "accession": "Q54972369", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54972369" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BC" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-korigi", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-korigi" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-korigi)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:19102", "category": "Organism-specific databases", "database": "HGNC", "label": "RIGI", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19102" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-RIG-I" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BC", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BC" }, { "accession": "thpd-korigi", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-korigi" }, { "accession": "Q107117068", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117068" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8F8" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kosamhd1", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kosamhd1" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kosamhd1)" }, { "category": "Population", "value": "Japanese" } ], "created": "2025-04-10", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "2", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:15925", "category": "Organism-specific databases", "database": "HGNC", "label": "SAMHD1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15925" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-SAMHD1" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-kosamhd1", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kosamhd1" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AH" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [ { "accession": { "type": "primary", "value": "CVCL_A8BF" }, "name": { "type": "identifier", "value": "THP1-Dual KI-hSTING-A162" } }, { "accession": { "type": "primary", "value": "CVCL_A8BG" }, "name": { "type": "identifier", "value": "THP1-Dual KI-hSTING-H232" } }, { "accession": { "type": "primary", "value": "CVCL_A8BH" }, "name": { "type": "identifier", "value": "THP1-Dual KI-hSTING-M155" } }, { "accession": { "type": "primary", "value": "CVCL_A8BI" }, "name": { "type": "identifier", "value": "THP1-Dual KI-hSTING-R232" } }, { "accession": { "type": "primary", "value": "CVCL_A8BJ" }, "name": { "type": "identifier", "value": "THP1-Dual KI-hSTING-S154" } }, { "accession": { "type": "primary", "value": "CVCL_A8BD" }, "name": { "type": "identifier", "value": "THP1-Dual KI-mSTING" } } ], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kostg", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kostg" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kostg)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-STING" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AH" }, { "accession": "thpd-kostg", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kostg" }, { "accession": "Q107117071", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117071" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AY" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotbk", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotbk" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotbk)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:11584", "category": "Organism-specific databases", "database": "HGNC", "label": "TBK1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11584" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TBK1" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AY", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AY" }, { "accession": "thpd-kotbk", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotbk" }, { "accession": "Q107117072", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117072" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AW" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotlr2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr2" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotlr2)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:11848", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR2", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11848" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TLR2" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AW", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AW" }, { "accession": "thpd-kotlr2", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr2" }, { "accession": "Q107117074", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117074" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AX" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotlr4", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr4" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotlr4)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:11850", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR4", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11850" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TLR4" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AX", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AX" }, { "accession": "thpd-kotlr4", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr4" }, { "accession": "Q107117076", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117076" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BW" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotlr8", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr8" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotlr8)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:15632", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR8", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15632" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TLR8" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BW", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BW" }, { "accession": "thpd-kotlr8", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotlr8" }, { "accession": "Q107117078", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117078" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AJ" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotrex", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotrex" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotrex)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:12269", "category": "Organism-specific databases", "database": "HGNC", "label": "TREX1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12269" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TREX1" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8AJ", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8AJ" }, { "accession": "thpd-kotrex", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotrex" }, { "accession": "Q107117079", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117079" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8AM" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-kotrif", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-kotrif" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotrif)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:18348", "category": "Organism-specific databases", "database": "HGNC", "label": "TICAM1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18348" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KO-TRIF" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens 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"database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM236831" }, { "accession": "GSM887338", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM887338" }, { "accession": "GSM888414", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM888414" }, { "accession": "GSM1374692", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1374692" }, { "accession": "GSM1670130", "category": "Gene expression databases", "database": "GEO", "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1670130" }, { "accession": "21514", "category": "Polymorphism and mutation databases", "database": "IARC_TP53" }, { "accession": "HTL01015", "category": "Cell line collections (Providers)", "database": "ICLC", "url": "http://www.iclc.it/details/det_list.php?line_id=HTL01015" }, { "accession": "CCLE_095", "category": "Polymorphism and mutation databases", "database": "LiGeA", "url": "http://hpc-bioinformatics.cineca.it/fusion/cell_line/CCLE_095" }, { "accession": "LCL-1063", "category": "Cell line databases/resources", "database": "LINCS_LDP", "url": "http://lincsportal.ccs.miami.edu/cells/#/view/LCL-1063" }, { "accession": "4", "category": "Cell line databases/resources", "database": "Lonza", "url": "https://knowledge.lonza.com/cell?id=4" }, { "accession": "MONOMAC6_960_2019", "category": "Chemistry resources", "database": "PharmacoDB", "url": "https://pharmacodb.ca/cell_lines/MONOMAC6_960_2019" }, { "accession": "PXD030304", "category": "Proteomic databases", "database": "PRIDE", "url": "https://www.ebi.ac.uk/pride/archive/projects/PXD030304" }, { "accession": "CVCL_1426", "category": "Polymorphism and mutation databases", "database": "Progenetix", "url": "https://progenetix.org/cellline/?id=cellosaurus:CVCL_1426" }, { "accession": "CVCL_1426", "category": "Chemistry resources", "database": "PubChem_Cell_line", "url": "https://pubchem.ncbi.nlm.nih.gov/cell/CVCL_1426" }, { "accession": "Q54906378", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q54906378" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BZ" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpdf-hlc3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpdf-hlc3" } } ], "value": "Stably expresses a RFP-GFP-MAP1LC3B construct (InvivoGen=thpdf-hlc3)" }, { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpdf-hlc3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpdf-hlc3" } } ], "value": "Allows monitoring of autophagic flux in real time by detecting the appearance of dual red and green RFP:GFP:LC3 puncta or single red RFP:LC3 puncta by fluorescence microscopy. Early in autophagy, both RFP and GFP signals are detected. As the fusion of the autophagosomes with the lysosomes progresses, the GFP fluorescence diminishes, leaving only the RFP fluorescence visible. The percentages of RFP-GFP positive and of RFP positive cells can be determined and these values can be used to assess autophagic flux (InvivoGen=thpdf-hlc3)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_X601", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Null", "url": "https://www.cellosaurus.org/CVCL_X601" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "9", "genetic-integration-list": [ { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:13352", "category": "Organism-specific databases", "database": "HGNC", "label": "MAP1LC3B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13352" } }, { "genetic-integration-note": "Enhanced GFP", "method": "Transfection", "xref": { "accession": "R9NL8", "category": "Sequence databases", "database": "FPbase", "label": "eGFP", "url": "https://www.fpbase.org/protein/R9NL8/" } }, { "genetic-integration-note": "drFP583, red fluorescent protein from Discosoma sp.", "method": "Transfection", "xref": { "accession": "EGE3L", "category": "Sequence databases", "database": "FPbase", "label": "DsRed", "url": "https://www.fpbase.org/protein/EGE3L/" } } ], "last-updated": "2025-04-10", "name-list": [ { "type": "identifier", "value": "THP1-Difluo hLC3" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Null", "xref": { "accession": "CVCL_X601", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Null", "url": "https://www.cellosaurus.org/CVCL_X601" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Null", "xref": { "accession": "CVCL_X601", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Null", "url": "https://www.cellosaurus.org/CVCL_X601" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Null", "xref": { "accession": "CVCL_X601", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Null", "url": "https://www.cellosaurus.org/CVCL_X601" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Null", "xref": { "accession": "CVCL_X601", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Null", "url": "https://www.cellosaurus.org/CVCL_X601" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BZ", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BZ" }, { "accession": "thpdf-hlc3", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpdf-hlc3" }, { "accession": "Q107117044", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117044" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BF" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-a162", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-a162" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-a162)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "genetic-integration-note": "With p.Ser162Ala", "method": "Transfection", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KI-hSTING-A162" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BF", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BF" }, { "accession": "thpd-a162", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-a162" }, { "accession": "Q107117045", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117045" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BG" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-h232", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-h232" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-h232)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "genetic-integration-note": "With p.Arg232His", "method": "Transfection", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KI-hSTING-H232" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BG", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BG" }, { "accession": "thpd-h232", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-h232" }, { "accession": "Q107117047", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117047" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BH" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-m155", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-m155" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-m155)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "genetic-integration-note": "With p.Val155Met", "method": "Transfection", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KI-hSTING-M155" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BH", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BH" }, { "accession": "thpd-m155", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-m155" }, { "accession": "Q107117049", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117049" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_A8BJ" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-s154", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-s154" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-s154)" }, { "category": "Population", "value": "Japanese" } ], "created": "2021-05-20", "derived-from": [ { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } ], "derived-from-site-list": [ { "site": { "site-type": "In situ", "value": "Peripheral blood", "xref-list": [ { "accession": "UBERON_0000178", "category": "Anatomy/cell type resources", "database": "UBERON", "iri": "http://purl.obolibrary.org/obo/UBERON_0000178", "label": "blood", "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000178" } ] } } ], "disease-list": [ { "accession": "C9163", "category": "Medical resources", "database": "NCIt", "iri": "http://purl.obolibrary.org/obo/NCIT_C9163", "label": "Childhood acute monocytic leukemia", "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9163" }, { "accession": "Orphanet_514", "category": "Medical resources", "database": "ORDO", "iri": "http://www.orpha.net/ORDO/Orphanet_514", "label": "Acute monoblastic/monocytic leukemia", "url": "https://www.ebi.ac.uk/ols4/ontologies/ordo/classes/http%253A%252F%252Fwww.orpha.net%252FORDO%252FOrphanet_514" } ], "entry-version": "11", "genetic-integration-list": [ { "genetic-integration-note": "Synthetic gene designed on natural secreted luciferase genes from marine copepods", "method": "Transfection", "value": "Synthetic construct Lucia luciferase" }, { "method": "Transfection", "xref": { "accession": "P17493", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P17493", "label": "Streptoalloteichus hindustanus ble (BleoR)", "url": "https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "genetic-integration-note": "With p.Asn154Ser", "method": "Transfection", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:27962", "category": "Organism-specific databases", "database": "HGNC", "label": "STING1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27962" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual KI-hSTING-S154" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific databases", "database": "HGNC", "label": "DDX39B", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13917" } ] }, { "mutation-description": "KMT2A-MLLT3, MLL-MLLT3, MLL-AF9", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:7132", "category": "Organism-specific databases", "database": "HGNC", "label": "KMT2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7132" }, { "accession": "HGNC:7136", "category": "Organism-specific databases", "database": "HGNC", "label": "MLLT3", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7136" } ] }, { "mutation-description": "p.Gly12Asp (c.35G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:7989", "category": "Organism-specific databases", "database": "HGNC", "label": "NRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7989" }, { "accession": "VCV000039648", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000039648" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Arg174fs*3 (c.520_545del26)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line THP1-Dual KO-STING", "xref": { "accession": "CVCL_A8AH", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual KO-STING", "url": "https://www.cellosaurus.org/CVCL_A8AH" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "CVCL_A8BJ", "category": "Cell line databases/resources", "database": "cancercelllines", "url": "https://cancercelllines.org/cellline/?id=cellosaurus:CVCL_A8BJ" }, { "accession": "thpd-s154", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-s154" }, { "accession": "Q107117053", "category": "Encyclopedic resources", "database": "Wikidata", "url": "https://www.wikidata.org/wiki/Q107117053" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FF" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-mckotlr4", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-mckotlr4" } } ], "value": "Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. 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"https://www.uniprot.org/uniprotkb/P17493/entry" } }, { "method": "Transfection", "xref": { "accession": "P33967", "category": "Sequence databases", "database": "UniProtKB", "iri": "http://purl.uniprot.org/uniprot/P33967", "label": "Bacillus cereus Bsr", "url": "https://www.uniprot.org/uniprotkb/P33967/entry" } }, { "method": "Transfection", "xref": { "accession": "HGNC:17156", "category": "Organism-specific databases", "database": "HGNC", "label": "LY96", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17156" } }, { "method": "Transfection", "xref": { "accession": "HGNC:1628", "category": "Organism-specific databases", "database": "HGNC", "label": "CD14", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1628" } }, { "method": "Transfection", "xref": { "accession": "HGNC:439", "category": "Organism-specific databases", "database": "HGNC", "label": "ALPP", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:439" } } ], "knockout-cell-list": [ { "method": "Not specified", "xref": { "accession": "HGNC:11850", "category": "Organism-specific databases", "database": "HGNC", "label": "TLR4", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11850" } } ], "last-updated": "2025-08-14", "name-list": [ { "type": "identifier", "value": "THP1-Dual MD2-CD14 KO-TLR4" } ], "sequence-variation-list": [ { "mutation-description": "CSNK2A1-DDX39B", "source-list": [ { "value": "from parent cell line THP1-Dual", "xref": { "accession": "CVCL_X599", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "THP1-Dual", "url": "https://www.cellosaurus.org/CVCL_X599" } } ], "variation-type": "Gene fusion", "xref-list": [ { "accession": "HGNC:2457", "category": "Organism-specific databases", "database": "HGNC", "label": "CSNK2A1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2457" }, { "accession": "HGNC:13917", "category": "Organism-specific 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"variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:11998", "category": "Organism-specific databases", "database": "HGNC", "label": "TP53", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998" } ], "zygosity-type": "Heterozygous" } ], "sex": "Male", "species-list": [ { "accession": "9606", "category": "Taxonomy", "database": "NCBI_TaxID", "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606", "label": "Homo sapiens (Human)", "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3" } ], "xref-list": [ { "accession": "thpd-mckotlr4", "category": "Cell line collections (Providers)", "database": "InvivoGen", "url": "https://www.invivogen.com/search?sq=thpd-mckotlr4" } ] }, { "accession-list": [ { "type": "primary", "value": "CVCL_E8FE" } ], "age": "1Y", "category": "Cancer cell line", "child-list": [], "comment-list": [ { "category": "Characteristics", "source-list": [ { "xref": { "accession": "thpd-mctlr4", 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116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:1787", "category": "Organism-specific databases", "database": "HGNC", "label": "CDKN2A", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1787" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Ser45del (c.133_135delTCT)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line HCT 116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:2514", "category": "Organism-specific databases", "database": "HGNC", "label": "CTNNB1", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2514" }, { "accession": "VCV000017576", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000017576" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Met1470Cysfs*22 (c.4408delA)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line HCT 116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:3373", "category": "Organism-specific databases", "database": "HGNC", "label": "EP300", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3373" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Asn1700Thrfs*9 (c.5099delA)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line HCT 116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:3373", "category": "Organism-specific databases", "database": "HGNC", "label": "EP300", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3373" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.Gly13Asp (c.38G>A)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line HCT 116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:6407", "category": "Organism-specific databases", "database": "HGNC", "label": "KRAS", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6407" }, { "accession": "VCV000012580", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/VCV000012580" } ], "zygosity-type": "Heterozygous" }, { "mutation-description": "p.His1047Arg (c.3140A>G)", "mutation-type": "Simple", "source-list": [ { "value": "from parent cell line HCT 116", "xref": { "accession": "CVCL_0291", "category": "Cell line databases/resources", "database": "Cellosaurus", "label": "HCT 116", "url": "https://www.cellosaurus.org/CVCL_0291" } } ], "variation-type": "Mutation", "xref-list": [ { "accession": "HGNC:8975", "category": "Organism-specific databases", "database": "HGNC", "label": "PIK3CA", "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8975" }, { "accession": "VCV000013652", "category": "Polymorphism and mutation databases", "database": "ClinVar", "url": 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"Abcam THP-1 THBS1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C7ES" }, "name": { "type": "identifier", "value": "Abcam THP-1 TIMP2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AR" }, "name": { "type": "identifier", "value": "Abcam THP-1 TIMP3 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AS" }, "name": { "type": "identifier", "value": "Abcam THP-1 TLN1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_B1AL" }, "name": { "type": "identifier", "value": "Abcam THP-1 TNF KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AT" }, "name": { "type": "identifier", "value": "Abcam THP-1 TNFRSF10B KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AU" }, "name": { "type": "identifier", "value": "Abcam THP-1 TNFRSF1B KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AV" }, "name": { "type": "identifier", "value": "Abcam THP-1 TP73 KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PB" }, "name": { "type": "identifier", "value": "Abcam THP-1 TPM1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AW" }, "name": { "type": "identifier", "value": "Abcam THP-1 TRADD KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AX" }, "name": { "type": "identifier", "value": "Abcam THP-1 TRAF2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C7ET" }, "name": { "type": "identifier", "value": "Abcam THP-1 TRAP1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_B1AM" }, "name": { "type": "identifier", "value": "Abcam THP-1 TREM2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AY" }, "name": { "type": "identifier", "value": "Abcam THP-1 TRMT2A KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PC" }, "name": { "type": "identifier", "value": "Abcam THP-1 TUBA4A KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0AZ" }, "name": { "type": "identifier", "value": "Abcam THP-1 TWIST1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B0" }, "name": { "type": "identifier", "value": "Abcam THP-1 TWIST2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C7EV" }, "name": { "type": "identifier", "value": "Abcam THP-1 TXNIP KO" } }, { "accession": { "type": "primary", "value": "CVCL_C7EU" }, "name": { "type": "identifier", "value": "Abcam THP-1 TXNRD1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PD" }, "name": { "type": "identifier", "value": "Abcam THP-1 TYMS KO" } }, { "accession": { "type": "primary", "value": "CVCL_B7TG" }, "name": { "type": "identifier", "value": "Abcam THP-1 TYROBP KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B1" }, "name": { "type": "identifier", "value": "Abcam THP-1 U2AF1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B2" }, "name": { "type": "identifier", "value": "Abcam THP-1 UBA1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B3" }, "name": { "type": "identifier", "value": "Abcam THP-1 UBE2D2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B4" }, "name": { "type": "identifier", "value": "Abcam THP-1 UCHL5 KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PE" }, "name": { "type": "identifier", "value": "Abcam THP-1 UCP2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B5" }, "name": { "type": "identifier", "value": "Abcam THP-1 ULBP2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B6" }, "name": { "type": "identifier", "value": "Abcam THP-1 ULBP3 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B7" }, "name": { "type": "identifier", "value": "Abcam THP-1 UVRAG KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B8" }, "name": { "type": "identifier", "value": "Abcam THP-1 VAV1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0B9" }, "name": { "type": "identifier", "value": "Abcam THP-1 VCAN KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BA" }, "name": { "type": "identifier", "value": "Abcam THP-1 WDR77 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BB" }, "name": { "type": "identifier", "value": "Abcam THP-1 WNT11 KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PF" }, "name": { "type": "identifier", "value": "Abcam THP-1 XBP1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_D2PG" }, "name": { "type": "identifier", "value": "Abcam THP-1 XDH KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BC" }, "name": { "type": "identifier", "value": "Abcam THP-1 YTHDC2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BD" }, "name": { "type": "identifier", "value": "Abcam THP-1 YTHDF1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BE" }, "name": { "type": "identifier", "value": "Abcam THP-1 YTHDF3 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BF" }, "name": { "type": "identifier", "value": "Abcam THP-1 YY1 KO" } }, { "accession": { "type": "primary", "value": "CVCL_C0BG" }, "name": { "type": "identifier", "value": "Abcam THP-1 ZEB2 KO" } }, { "accession": { "type": "primary", "value": "CVCL_X687" }, "name": { "type": "identifier", "value": "BF24" } }, { "accession": { "type": "primary", "value": "CVCL_E8DQ" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 B2M KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DR" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 B2M/CIITA dKO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DS" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 CD36 KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DT" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 CIITA KO" } }, { "accession": { "type": "primary", "value": "CVCL_E8DU" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 FCGR1A KO" } }, { "accession": { "type": "primary", "value": "CVCL_F0PJ" }, "name": { "type": "identifier", "value": "BPS Bioscience THP-1 ISRE-driven luciferase reporter" } }, { "accession": { "type": "primary", "value": "CVCL_KB46" }, "name": { "type": "identifier", "value": "CellSensor NFkB-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_KS29" }, "name": { "type": "identifier", "value": "CellSensor SIE-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_KS30" }, "name": { "type": "identifier", "value": "CellSensor TNFalpha-bla THP-1" } }, { "accession": { "type": "primary", "value": "CVCL_F6J1" }, "name": { "type": "identifier", "value": "EDITGENE CD63 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F5BW" }, "name": { "type": "identifier", "value": "EDITGENE IL4I1 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F5Q8" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-Cas9" } }, { "accession": { "type": "primary", "value": "CVCL_F6A1" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-CopGFP" } }, { "accession": { "type": "primary", "value": "CVCL_F5SJ" }, "name": { "type": "identifier", "value": "EDITGENE THP-1-FLUC" } }, { "accession": { "type": "primary", "value": "CVCL_F6JI" }, "name": { "type": "identifier", "value": "EDITGENE TLR7 and TLR8 Knockout THP-1 Cell Line" } }, { "accession": { "type": "primary", "value": "CVCL_F4KS" }, "name": { "type": "identifier", "value": "HyCyte CT26 mKRAS_p.G12C_c.557G\uff1eT cell line" } }, { "accession": { "type": "primary", "value": "CVCL_F4KT" }, "name": { "type": "identifier", "value": "HyCyte CT26 mKRAS_p.G12C_c.558G\uff1eT cell line" } }, { "accession": { "type": "primary", "value": "CVCL_E2QA" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hADAP1_p.P14R_c.41C>G" } }, { "accession": { "type": "primary", "value": "CVCL_F4K8" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hIRF8_c.1278/insT/c.1279 cell line" } }, { "accession": { "type": "primary", "value": "CVCL_E2QB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hKDM6A_p.A694T_c.2080G>A" } }, { "accession": { "type": "primary", "value": "CVCL_F4KL" }, "name": { "type": "identifier", "value": "HyCyte THP-1 hLACC1_p.V254I_c.760G\uff1eA cell line" } }, { "accession": { "type": "primary", "value": "CVCL_F1TU" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hACSL4" } }, { "accession": { "type": "primary", "value": "CVCL_F4GH" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hAIM2" } }, { "accession": { "type": "primary", "value": "CVCL_D6CN" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCASP1" } }, { "accession": { "type": "primary", "value": "CVCL_F1TV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD22" } }, { "accession": { "type": "primary", "value": "CVCL_D6CP" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD274" } }, { "accession": { "type": "primary", "value": "CVCL_F1TW" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD33" } }, { "accession": { "type": "primary", "value": "CVCL_D6CQ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCD44" } }, { "accession": { "type": "primary", "value": "CVCL_F1TX" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCEBPB" } }, { "accession": { "type": "primary", "value": "CVCL_F1TY" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCGAS" } }, { "accession": { "type": "primary", "value": "CVCL_F4FR" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCNDP2" } }, { "accession": { "type": "primary", "value": "CVCL_F4F3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hCYBB" } }, { "accession": { "type": "primary", "value": "CVCL_F1TZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hDAPP1" } }, { "accession": { "type": "primary", "value": "CVCL_F4JG" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hDNASE2" } }, { "accession": { "type": "primary", "value": "CVCL_E1MY" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hELF4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U0" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hFPR2" } }, { "accession": { "type": "primary", "value": "CVCL_F4IQ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGPI" } }, { "accession": { "type": "primary", "value": "CVCL_F1U1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGPR39" } }, { "accession": { "type": "primary", "value": "CVCL_E1MZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGSDMD" } }, { "accession": { "type": "primary", "value": "CVCL_F1U2" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hGSDME" } }, { "accession": { "type": "primary", "value": "CVCL_E1N0" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hHNRNPA2B1" } }, { "accession": { "type": "primary", "value": "CVCL_F1U3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIFI27" } }, { "accession": { "type": "primary", "value": "CVCL_F1U4" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIL6R" } }, { "accession": { "type": "primary", "value": "CVCL_E1N1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIRAK4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U5" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hITGAM" } }, { "accession": { "type": "primary", "value": "CVCL_F4FB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hIVNS1ABP" } }, { "accession": { "type": "primary", "value": "CVCL_E1N2" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hLAMTOR2" } }, { "accession": { "type": "primary", "value": "CVCL_F1U6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hLINC01355" } }, { "accession": { "type": "primary", "value": "CVCL_E1N3" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMCFD2" } }, { "accession": { "type": "primary", "value": "CVCL_F1U7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMLKL" } }, { "accession": { "type": "primary", "value": "CVCL_F4H1" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hMT1G" } }, { "accession": { "type": "primary", "value": "CVCL_F4J7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hN4BP3" } }, { "accession": { "type": "primary", "value": "CVCL_E1N4" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNCF1" } }, { "accession": { "type": "primary", "value": "CVCL_F4GC" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNEDD4" } }, { "accession": { "type": "primary", "value": "CVCL_F1U8" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNR1H3" } }, { "accession": { "type": "primary", "value": "CVCL_F1U9" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hNSUN3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UA" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hOASL" } }, { "accession": { "type": "primary", "value": "CVCL_E1N5" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hOSM" } }, { "accession": { "type": "primary", "value": "CVCL_F1UB" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPGAM5" } }, { "accession": { "type": "primary", "value": "CVCL_F4HL" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPI4KA" } }, { "accession": { "type": "primary", "value": "CVCL_F1UC" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPLD3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UD" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hPYCARD" } }, { "accession": { "type": "primary", "value": "CVCL_F1UE" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSERPINB3" } }, { "accession": { "type": "primary", "value": "CVCL_E1N6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSETDB2" } }, { "accession": { "type": "primary", "value": "CVCL_F4GV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSIRPA" } }, { "accession": { "type": "primary", "value": "CVCL_E1N7" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hSMAD3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UF" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTARM1" } }, { "accession": { "type": "primary", "value": "CVCL_F1UG" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTBK1" } }, { "accession": { "type": "primary", "value": "CVCL_F1UH" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTGFBR1" } }, { "accession": { "type": "primary", "value": "CVCL_D6CR" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTHRAP3" } }, { "accession": { "type": "primary", "value": "CVCL_F1UI" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTLR4" } }, { "accession": { "type": "primary", "value": "CVCL_D6CS" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTNF" } }, { "accession": { "type": "primary", "value": "CVCL_F4HZ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hTRAF2 and hTRAF2" } }, { "accession": { "type": "primary", "value": "CVCL_D6CT" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hUSP10" } }, { "accession": { "type": "primary", "value": "CVCL_F1UJ" }, "name": { "type": "identifier", "value": "HyCyte THP-1 KO-hVCPIP1" } }, { "accession": { "type": "primary", "value": "CVCL_F4SV" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hCHRM3 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4NX" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hDAPP1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4PK" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hNR1H3 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4R9" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hPDHA1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4T6" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hSTING1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_F4MS" }, "name": { "type": "identifier", "value": "HyCyte THP-1 stable cell line for hSYVN1 overexpression" } }, { "accession": { "type": "primary", "value": "CVCL_E3IS" }, "name": { "type": "identifier", "value": "HyCyte THP-1-Luc" } }, { "accession": { "type": "primary", "value": "CVCL_KZ70" }, "name": { "type": "identifier", "value": "PathHunter THP-1 IkappaB Degradation" } }, { "accession": { "type": "primary", "value": "CVCL_IR08" }, "name": { "type": "identifier", "value": "PSC-THP1" } }, { "accession": { "type": "primary", "value": "CVCL_A4CA" }, "name": { "type": "identifier", "value": "THP-1 AP1-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_A4CB" }, "name": { "type": "identifier", "value": "THP-1 CRE-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_A4CD" }, "name": { "type": "identifier", "value": "THP-1 GAS-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_E7CQ" }, "name": { "type": "identifier", "value": "THP-1 IQAD biosensor" } }, { "accession": { "type": "primary", "value": "CVCL_A4CC" }, "name": { "type": "identifier", "value": "THP-1 ISRE-Luc2" } }, { "accession": { "type": "primary", "value": "CVCL_F1K5" }, "name": { "type": "identifier", "value": "THP-1 K5 P/A" } }, { "accession": { "type": "primary", "value": "CVCL_F1K6" }, "name": { "type": "identifier", "value": "THP-1 K5 WT" } }, { "accession": { "type": "primary", "value": "CVCL_F1K7" }, "name": { "type": "identifier", "value": "THP-1 K5 Y/A" } }, { "accession": { "type": "primary", "value": "CVCL_E2QQ" }, "name": { "type": "identifier", "value": "THP-1 NF-kappaB-eGFP" } }, { "accession": { "type": "primary", "value": "CVCL_A4CE" }, "name": { "type": "identifier", "value": "THP-1 NF-kB-Luc2" } }, { "accession": { "type": "primary", "value": 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