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            "name": {
              "type": "identifier",
              "value": "ATG2B-KO HeLa"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_1904"
            },
            "name": {
              "type": "identifier",
              "value": "AV3"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_0164"
            },
            "name": {
              "type": "identifier",
              "value": "BCaP-37"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_A033"
            },
            "name": {
              "type": "identifier",
              "value": "BCC-1/KMC"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_5492"
            },
            "name": {
              "type": "identifier",
              "value": "BEL-7402"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6568"
            },
            "name": {
              "type": "identifier",
              "value": "BEL-7404"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3360"
            },
            "name": {
              "type": "identifier",
              "value": "BGC-823"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_E8DG"
            },
            "name": {
              "type": "identifier",
              "value": "BPS Bioscience HeLa PARG KO"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_E8DH"
            },
            "name": {
              "type": "identifier",
              "value": "BPS Bioscience HeLa PARP1 KO"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D280"
            },
            "name": {
              "type": "identifier",
              "value": "BrCA 5"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_1858"
            },
            "name": {
              "type": "identifier",
              "value": "BT-B [Human HeLa contaminated cell line]"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2322"
            },
            "name": {
              "type": "identifier",
              "value": "C16"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_UY83"
            },
            "name": {
              "type": "identifier",
              "value": "CaES-17"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_M091"
            },
            "name": {
              "type": "identifier",
              "value": "CaOV"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8444"
            },
            "name": {
              "type": "identifier",
              "value": "CaVe"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_KS05"
            },
            "name": {
              "type": "identifier",
              "value": "CellSensor ESRE-bla HeLa"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_KS08"
            },
            "name": {
              "type": "identifier",
              "value": "CellSensor HSE-bla HeLa"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_KS75"
            },
            "name": {
              "type": "identifier",
              "value": "CellSensor MMTV-bla HeLa"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_KS77"
            },
            "name": {
              "type": "identifier",
              "value": "CellSensor T-REx FOXO3-DBE-bla HeLa"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_KS76"
            },
            "name": {
              "type": "identifier",
              "value": "CellSensor T-REx NICD-CSL-bla HeLa"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_0238"
            },
            "name": {
              "type": "identifier",
              "value": "Chang Liver"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_M022"
            },
            "name": {
              "type": "identifier",
              "value": "CM-319"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D297"
            },
            "name": {
              "type": "identifier",
              "value": "CMP [Human contaminated rectal cancer]"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_L115"
            },
            "name": {
              "type": "identifier",
              "value": "CMPII C2"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6888"
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              "type": "identifier",
              "value": "CNE-1"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6889"
            },
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              "type": "identifier",
              "value": "CNE-2"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8669"
            },
            "name": {
              "type": "identifier",
              "value": "D18T"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D279"
            },
            "name": {
              "type": "identifier",
              "value": "DAPT"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8674"
            },
            "name": {
              "type": "identifier",
              "value": "Detroit 30A"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2436"
            },
            "name": {
              "type": "identifier",
              "value": "Detroit 6"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8188"
            },
            "name": {
              "type": "identifier",
              "value": "Detroit 98"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8344"
            },
            "name": {
              "type": "identifier",
              "value": "EB33"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_E307"
            },
            "name": {
              "type": "identifier",
              "value": "EC9706"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F5AJ"
            },
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              "type": "identifier",
              "value": "EDITGENE ACAP3 Knockout Hela Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6I2"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE ACOT8 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6EI"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE ACSBG2 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6EG"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE ADRB2 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6CY"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE BNIP3 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6EQ"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE BTRC Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6EP"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE CCNL2 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6I9"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE CD274 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6HS"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE CERT1 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6DK"
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            "name": {
              "type": "identifier",
              "value": "EDITGENE CRBN Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6F2"
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              "type": "identifier",
              "value": "EDITGENE DCAF16 Knockout HeLa Cell Line"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6JN"
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              "type": "identifier",
              "value": "EDITGENE DDIAS Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6D5"
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              "type": "identifier",
              "value": "EDITGENE DSG1 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6EM"
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              "type": "identifier",
              "value": "EDITGENE FBXW7 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F6J8"
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              "type": "identifier",
              "value": "EDITGENE GBA1 Knockout HeLa Cell Line"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F5Q7"
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              "type": "identifier",
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F5ZC"
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              "type": "identifier",
              "value": "EDITGENE hela-CopGFP"
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          },
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            "accession": {
              "type": "primary",
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          },
          {
            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6F7"
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              "type": "identifier",
              "value": "EDITGENE ITGB8 Knockout HeLa Cell Line"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6EW"
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              "type": "identifier",
              "value": "EDITGENE MKNK1 and MKNK2 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6CZ"
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              "type": "identifier",
              "value": "EDITGENE NPR1 Knockout HeLa Cell Line"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6HR"
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              "type": "identifier",
              "value": "EDITGENE NPR2 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6DE"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6DF"
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              "type": "identifier",
              "value": "EDITGENE OPTN Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6E9"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6DG"
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              "type": "identifier",
              "value": "EDITGENE PIP4P1 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6D4"
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              "type": "identifier",
              "value": "EDITGENE SLC12A1 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6HA"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6JC"
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              "type": "identifier",
              "value": "EDITGENE SQSTM1 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6EF"
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              "type": "identifier",
              "value": "EDITGENE STUB1 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6F3"
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              "type": "identifier",
              "value": "EDITGENE SYNJ1 Knockout HeLa Cell Line"
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            "accession": {
              "type": "primary",
              "value": "CVCL_F6E7"
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              "type": "identifier",
              "value": "EDITGENE TRIM21 Knockout HeLa Cell Line"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_8686"
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              "type": "identifier",
              "value": "ElCo"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8193"
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              "type": "identifier",
              "value": "EPLC-32M1"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8194"
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              "value": "EPLC-65H"
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            "accession": {
              "type": "primary",
              "value": "CVCL_8351"
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              "type": "identifier",
              "value": "ESP-1"
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            "accession": {
              "type": "primary",
              "value": "CVCL_7262"
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              "type": "identifier",
              "value": "EUE"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_8688"
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              "type": "identifier",
              "value": "F255A4"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_1905"
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              "type": "identifier",
              "value": "FL"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6395"
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              "type": "identifier",
              "value": "GH329"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6396"
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              "type": "identifier",
              "value": "GH354"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_K171"
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              "type": "identifier",
              "value": "GH364"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2254"
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              "type": "identifier",
              "value": "Girardi Heart"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3371"
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              "type": "identifier",
              "value": "GLC-82"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_WL58"
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              "type": "identifier",
              "value": "GNM"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_7669"
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              "type": "identifier",
              "value": "H-494"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3334"
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              "type": "identifier",
              "value": "H1HeLa"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_F269"
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              "type": "identifier",
              "value": "H454"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D281"
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              "type": "identifier",
              "value": "HBT-3"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_J652"
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              "type": "identifier",
              "value": "HBT-39b"
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_M619"
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              "type": "identifier",
              "value": "HCE"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_M624"
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              "type": "identifier",
              "value": "HEK"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_1276"
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              "type": "identifier",
              "value": "HeLa 229"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3379"
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              "type": "identifier",
              "value": "HeLa 382"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3380"
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              "type": "identifier",
              "value": "HeLa 422"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3381"
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              "type": "identifier",
              "value": "HeLa 432"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2933"
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            "name": {
              "type": "identifier",
              "value": "HeLa AG"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_B3SH"
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              "type": "identifier",
              "value": "HeLa ANXA11 KO"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2482"
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              "type": "identifier",
              "value": "HeLa B"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_W341"
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              "type": "identifier",
              "value": "HeLa B-50"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_W342"
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              "type": "identifier",
              "value": "HeLa C12"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_U339"
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            "name": {
              "type": "identifier",
              "value": "HeLa CD4+ Clone1022"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_X634"
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            "name": {
              "type": "identifier",
              "value": "HeLa CD4-Clone 6C"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2483"
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            "name": {
              "type": "identifier",
              "value": "HeLa DH"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_ZF12"
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              "type": "identifier",
              "value": "HeLa E"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_JA21"
            },
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              "type": "identifier",
              "value": "HeLa EV2"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_E6Z9"
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            "name": {
              "type": "identifier",
              "value": "HeLa fat-1"
            }
          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_ZM01"
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            "name": {
              "type": "identifier",
              "value": "HeLa FLAG-SNAP-hTERT"
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          },
          {
            "accession": {
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            "accession": {
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_1907"
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            "name": {
              "type": "identifier",
              "value": "Intestine 407"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_2965"
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            "name": {
              "type": "identifier",
              "value": "J-111"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_3990"
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              "type": "identifier",
              "value": "J-96"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_M093"
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              "type": "identifier",
              "value": "JHC"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8362"
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            "name": {
              "type": "identifier",
              "value": "JTC-17"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_A034"
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            "name": {
              "type": "identifier",
              "value": "JTC-3"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_0372"
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            "name": {
              "type": "identifier",
              "value": "KB"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_7963"
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              "type": "identifier",
              "value": "KCC-MS871"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_7966"
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              "type": "identifier",
              "value": "KCC-TCM901"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D283"
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              "type": "identifier",
              "value": "KP-P1"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_4714"
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              "type": "identifier",
              "value": "KU-7"
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          {
            "accession": {
              "type": "primary",
              "value": "CVCL_6926"
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              "type": "identifier",
              "value": "L-02"
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          {
            "accession": {
              "type": "primary",
              "value": "CVCL_1908"
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              "type": "identifier",
              "value": "L-132"
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            "accession": {
              "type": "primary",
              "value": "CVCL_ZJ09"
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              "type": "identifier",
              "value": "LanthaScreen c-Jun (1-79) HeLa"
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            "accession": {
              "type": "primary",
              "value": "CVCL_8438"
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              "type": "identifier",
              "value": "Led-T1"
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            "accession": {
              "type": "primary",
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              "type": "identifier",
              "value": "Leeporter HeLa ATF6 luciferase"
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          },
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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          },
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            "accession": {
              "type": "primary",
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              "type": "identifier",
              "value": "Leeporter HeLa p53 luciferase"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D7AC"
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              "type": "identifier",
              "value": "Leeporter HeLa STAT1 luciferase"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_D7AD"
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            "name": {
              "type": "identifier",
              "value": "Leeporter HeLa TLR4/IL-8 luciferase"
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_YJ81"
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              "type": "identifier",
              "value": "LINTERNA HeLa"
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            "accession": {
              "type": "primary",
              "value": "CVCL_6929"
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              "type": "identifier",
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            "accession": {
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              "value": "LU"
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          },
          {
            "accession": {
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            "accession": {
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            "accession": {
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            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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            "accession": {
              "type": "primary",
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              "value": "MC4000"
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_8264"
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              "type": "identifier",
              "value": "Minnesota EE"
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            "accession": {
              "type": "primary",
              "value": "CVCL_4243"
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              "type": "identifier",
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          },
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            "accession": {
              "type": "primary",
              "value": "CVCL_0441"
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              "type": "identifier",
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          },
          {
            "accession": {
              "type": "primary",
              "value": "CVCL_0461"
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              "type": "identifier",
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          {
            "accession": {
              "type": "primary",
              "value": "CVCL_8156"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_J350"
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              "type": "identifier",
              "value": "OE"
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            "accession": {
              "type": "primary",
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              "type": "identifier",
              "value": "OF"
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            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
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              "type": "identifier",
              "value": "OST"
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            "accession": {
              "type": "primary",
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            "accession": {
              "type": "primary",
              "value": "CVCL_6859"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
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            "accession": {
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            "accession": {
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            "accession": {
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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            "accession": {
              "type": "primary",
              "value": "CVCL_1680"
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              "type": "identifier",
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            "accession": {
              "type": "primary",
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            "accession": {
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            "accession": {
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            "accession": {
              "type": "primary",
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              "type": "identifier",
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            "accession": {
              "type": "primary",
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            "accession": {
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            "accession": {
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            "accession": {
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            "accession": {
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            "accession": {
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        "comment-list": [
          {
            "category": "Miscellaneous",
            "value": "HeLa is the most frequent contributor to cell lines contamination"
          },
          {
            "category": "Anecdotal",
            "value": "Was flown since the 1960s on at least ten different space missions: Korabl-Sputnik-2, Vostok-1, Vostok-4, Vostok-5 and Vostok-6, Voshkod 1 and Zond-5, Discoverer XVIII, Progress M-35/Mir and Shuttle STS-89"
          },
          {
            "category": "Anecdotal",
            "value": "The HeLa cell line and its story inspired Australian artist Cynthia Verspaget to embark in 2003 on a artistic project 'The Anarchy Cell Line' (TAnCL) where she mixed her blood with HeLa cells. This work later spawned a PhD thesis (CelloPub=CLPUB00376) where among other things she makes the observation that two main taxonomical distinctions present in the zombie, living/dead and human/nonhuman, are also present in the HeLa cell line"
          },
          {
            "category": "Anecdotal",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "CelloPub=CLPUB00377"
                }
              }
            ],
            "value": "The fascinating story of the HeLa cell line and of Henrietta Lacks from whom these cells originate are described in the book of Rebecca Skloot (CelloPub=CLPUB00377)"
          },
          {
            "category": "Anecdotal",
            "value": "The HeLa cell line which was established in February 1951 is the oldest human immortal cell line"
          },
          {
            "category": "Virology",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=33389257"
                }
              }
            ],
            "value": "Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)"
          },
          {
            "category": "Virology",
            "value": "HeLa has 5 five HPV18 integration sites: three on normal chromosomes 8 at 8q24 and two on derivative chromosomes, der(5)t(5;22;8)(q11;q11q13;q24) and der(22)t(8;22) (q24;q13)"
          },
          {
            "category": "Population",
            "value": "African American"
          },
          {
            "category": "Part of",
            "value": "Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982)"
          },
          {
            "category": "Part of",
            "value": "MD Anderson Cell Lines Project"
          },
          {
            "category": "Part of",
            "value": "Human Protein Atlas, Cell Atlas panel"
          },
          {
            "category": "Part of",
            "value": "COSMIC cell lines project"
          },
          {
            "category": "Part of",
            "value": "Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)"
          },
          {
            "category": "Group",
            "value": "Space-flown cell line (cellonaut)"
          }
        ],
        "created": "2012-04-04",
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
                }
              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "doubling-time-list": [
          {
            "doubling-time-value": "30-48 hours",
            "source-list": [
              {
                "xref": {
                  "accession": "TCH-C193",
                  "category": "Cell line collections (Providers)",
                  "database": "Hysigen",
                  "url": "https://hysigen.com/TCH-C193.html"
                }
              }
            ]
          },
          {
            "doubling-time-value": "~48 hours",
            "source-list": [
              {
                "xref": {
                  "accession": "ACC-57",
                  "category": "Cell line collections (Providers)",
                  "database": "DSMZ",
                  "url": "https://www.dsmz.de/collection/catalogue/details/culture/ACC-57"
                }
              }
            ]
          },
          {
            "doubling-time-value": "1.3 days",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=29156801"
                }
              }
            ]
          }
        ],
        "doubling-time-range": {
          "max": "48",
          "min": "30",
          "unit": "hour"
        },
        "entry-version": "53",
        "genome-ancestry": {
          "population-list": [
            {
              "population-name": "African",
              "population-percentage": "64.74"
            },
            {
              "population-name": "Native American",
              "population-percentage": "0.77"
            },
            {
              "population-name": "East Asian, North",
              "population-percentage": "2.26"
            },
            {
              "population-name": "East Asian, South",
              "population-percentage": "0"
            },
            {
              "population-name": "South Asian",
              "population-percentage": "0"
            },
            {
              "population-name": "European, North",
              "population-percentage": "19.45"
            },
            {
              "population-name": "European, South",
              "population-percentage": "12.78"
            }
          ],
          "source": {
            "reference": {
              "resource-internal-ref": "PubMed=30894373"
            }
          }
        },
        "hla-typing-list": [
          {
            "hla-gene-alleles-list": [
              {
                "alleles": "03,28",
                "gene": "HLA-A"
              },
              {
                "alleles": "w15,w35",
                "gene": "HLA-B"
              },
              {
                "alleles": "w02,w03",
                "gene": "HLA-C"
              }
            ],
            "source": {
              "reference": {
                "resource-internal-ref": "PubMed=77569"
              }
            }
          },
          {
            "hla-gene-alleles-list": [
              {
                "alleles": "03:19,68:02",
                "gene": "HLA-A"
              },
              {
                "alleles": "15:03,15:03",
                "gene": "HLA-B"
              },
              {
                "alleles": "12:03,12:03",
                "gene": "HLA-C"
              },
              {
                "alleles": "01:02,01:02",
                "gene": "HLA-DRB1"
              }
            ],
            "source": {
              "reference": {
                "resource-internal-ref": "PubMed=25960936"
              }
            }
          },
          {
            "hla-gene-alleles-list": [
              {
                "alleles": "68:02,68:02",
                "gene": "HLA-A"
              },
              {
                "alleles": "15:03,15:03",
                "gene": "HLA-B"
              },
              {
                "alleles": "12:03,12:03",
                "gene": "HLA-C"
              },
              {
                "alleles": "01:02,01:02",
                "gene": "HLA-DQA1"
              },
              {
                "alleles": "05:01,05:01",
                "gene": "HLA-DQB1"
              },
              {
                "alleles": "01:02,01:02",
                "gene": "HLA-DRB1"
              }
            ],
            "source": {
              "reference": {
                "resource-internal-ref": "PubMed=26589293"
              }
            }
          }
        ],
        "last-updated": "2026-06-25",
        "microsatellite-instability-list": [
          {
            "msi-value": "Stable (MSS)",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=12661003"
                }
              },
              {
                "institution": "Sanger",
                "value": "Sanger"
              }
            ]
          }
        ],
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa"
          },
          {
            "type": "synonym",
            "value": "HELA"
          },
          {
            "type": "synonym",
            "value": "Hela"
          },
          {
            "type": "synonym",
            "value": "He La"
          },
          {
            "type": "synonym",
            "value": "He-La"
          },
          {
            "type": "synonym",
            "value": "HeLa-CCL2"
          },
          {
            "type": "synonym",
            "value": "Henrietta Lacks cells"
          },
          {
            "type": "synonym",
            "value": "Helacyton gartleri"
          }
        ],
        "omics-list": [
          {
            "branch": "Genomics",
            "value": "DNA methylation analysis."
          },
          {
            "branch": "Genomics",
            "value": "Whole exome sequencing."
          },
          {
            "branch": "Genomics",
            "value": "Whole genome sequencing."
          },
          {
            "branch": "Phenotyping",
            "value": "Drug screening."
          },
          {
            "branch": "Proteomics"
          },
          {
            "branch": "Proteomics",
            "value": "Expression; Large antibody panel staining analysis."
          },
          {
            "branch": "Proteomics",
            "value": "Expression; Reverse-phase protein array."
          },
          {
            "branch": "Proteomics",
            "value": "PTM; Glycoproteome."
          },
          {
            "branch": "Proteomics",
            "value": "PTM; Myristoylation."
          },
          {
            "branch": "Proteomics",
            "value": "PTM; Phosphorylation."
          },
          {
            "branch": "Proteomics",
            "value": "Quantitative."
          },
          {
            "branch": "Proteomics",
            "value": "Subcellular; Cell surface."
          },
          {
            "branch": "Proteomics",
            "value": "Subcellular; Membrane."
          },
          {
            "branch": "Proteomics",
            "value": "Subcellular; Secretome; 2DE-MS."
          },
          {
            "branch": "Proteomics",
            "value": "Virome."
          },
          {
            "branch": "Transcriptomics",
            "value": "Microarray."
          },
          {
            "branch": "Transcriptomics",
            "value": "RNAseq."
          },
          {
            "branch": "Transcriptomics",
            "value": "RNAseq; Single cell."
          },
          {
            "branch": "Variations",
            "value": "CNV analysis."
          },
          {
            "branch": "Variations",
            "value": "SNP array analysis."
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "CelloPub=CLPUB00047"
          },
          {
            "resource-internal-ref": "CelloPub=CLPUB00262"
          },
          {
            "resource-internal-ref": "CelloPub=CLPUB00376"
          },
          {
            "resource-internal-ref": "CelloPub=CLPUB00377"
          },
          {
            "resource-internal-ref": "CelloPub=CLPUB00468"
          },
          {
            "resource-internal-ref": "CelloPub=CLPUB00507"
          },
          {
            "resource-internal-ref": "DOI=10.1007/978-1-4757-1647-4_13"
          },
          {
            "resource-internal-ref": "DOI=10.1007/BF02618370"
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          {
            "resource-internal-ref": "PubMed=77569"
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          {
            "resource-internal-ref": "PubMed=1246620"
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          {
            "resource-internal-ref": "PubMed=1522048"
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          {
            "resource-internal-ref": "PubMed=2983228"
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          {
            "resource-internal-ref": "PubMed=2990217"
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          {
            "resource-internal-ref": "PubMed=3028716"
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          {
            "resource-internal-ref": "PubMed=3180844"
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          {
            "resource-internal-ref": "PubMed=3371749"
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          {
            "resource-internal-ref": "PubMed=3518877"
          },
          {
            "resource-internal-ref": "PubMed=4942173"
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          {
            "resource-internal-ref": "PubMed=5668122"
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          {
            "resource-internal-ref": "PubMed=6256643"
          },
          {
            "resource-internal-ref": "PubMed=6358339"
          },
          {
            "resource-internal-ref": "PubMed=6401685"
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          {
            "resource-internal-ref": "PubMed=6825208"
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          {
            "resource-internal-ref": "PubMed=6935474"
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          {
            "resource-internal-ref": "PubMed=8380785"
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          {
            "resource-internal-ref": "PubMed=9892199"
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          {
            "resource-internal-ref": "PubMed=10423141"
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          {
            "resource-internal-ref": "PubMed=11416159"
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            "resource-internal-ref": "PubMed=11668190"
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            "resource-internal-ref": "PubMed=12001993"
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            "resource-internal-ref": "PubMed=19450234"
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            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
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            {
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              "id": "Amelogenin",
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                {
                  "marker-alleles": "X"
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              ]
            },
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                      }
                    },
                    {
                      "xref": {
                        "accession": "1298134",
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                      }
                    }
                  ]
                },
                {
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                  "source-list": [
                    {
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                    },
                    {
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                    },
                    {
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                    {
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                      "value": "Technion Genomics Center"
                    },
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                      "value": "CCRID"
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                },
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                  "marker-alleles": "12,14",
                  "source-list": [
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                      "xref": {
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                        "url": "https://www.culturecollections.org.uk/products/celllines/detail.jsp?refId=93021013"
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                  ]
                },
                {
                  "marker-alleles": "13,13.3",
                  "source-list": [
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                        "url": "https://www.cytion.com/300194"
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                  ]
                }
              ]
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            "value": "Engineered to express the gp160 envelope protein (Env) from a CXCR4-tropic HIV-1 isolate as well as a Tat-GFP fusion protein (PubMed=16314403)"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2017-05-15",
        "derived-from": [
          {
            "accession": "CVCL_IY74",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa Tet-On",
            "url": "https://www.cellosaurus.org/CVCL_IY74"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
                }
              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "14",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Met1_Arg360del",
            "method": "Transfection/transduction",
            "xref": {
              "accession": "P06492",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P06492",
              "label": "Human herpesvirus 1 (HHV-1) VP16 (UL28)",
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            }
          },
          {
            "method": "Transfection/transduction",
            "xref": {
              "accession": "P04483",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P04483",
              "label": "Escherichia coli Tn10 tetR",
              "url": "https://www.uniprot.org/uniprotkb/P04483/entry"
            }
          },
          {
            "method": "Transfection",
            "xref": {
              "accession": "Q72502",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/Q72502",
              "label": "HIV-1 isolate NL4-3 env",
              "url": "https://www.uniprot.org/uniprotkb/Q72502/entry"
            }
          },
          {
            "method": "Transfection",
            "xref": {
              "accession": "P04610",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P04610",
              "label": "HIV-1 isolate BRU/LAI tat",
              "url": "https://www.uniprot.org/uniprotkb/P04610/entry"
            }
          },
          {
            "method": "Transfection",
            "xref": {
              "accession": "P00557",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P00557",
              "label": "Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR)",
              "url": "https://www.uniprot.org/uniprotkb/P00557/entry"
            }
          },
          {
            "genetic-integration-note": "avGFP; original A.victoria green fluorescent protein",
            "method": "Transfection",
            "xref": {
              "accession": "1XF1B",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "GFP",
              "url": "https://www.fpbase.org/protein/1XF1B/"
            }
          }
        ],
        "last-updated": "2025-08-14",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa-X4"
          },
          {
            "type": "synonym",
            "value": "HeLa-X4-6"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=16314403"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
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          }
        ],
        "xref-list": [
          {
            "accession": "Q54882735",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54882735"
          }
        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_JZ15"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2017-08-22",
        "derived-from": [
          {
            "accession": "CVCL_0030",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa",
            "url": "https://www.cellosaurus.org/CVCL_0030"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
                }
              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "9",
        "genetic-integration-list": [
          {
            "method": "Transfection/transduction",
            "xref": {
              "accession": "P07385",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P07385",
              "label": "Cowpox virus crmA",
              "url": "https://www.uniprot.org/uniprotkb/P07385/entry"
            }
          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/crmA"
          },
          {
            "type": "synonym",
            "value": "HeLa-crmA"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=7667287"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
              "label": "Human papillomavirus type 18 (HPV18)",
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            }
          }
        ],
        "xref-list": [
          {
            "accession": "Q54882694",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54882694"
          }
        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_C869"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Miscellaneous",
            "value": "Formerly the CCRID database had an entry describing this cell line (3142C0001000000056). It was the sole source of information for this entry"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2012-10-22",
        "derived-from": [
          {
            "accession": "CVCL_0030",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa",
            "url": "https://www.cellosaurus.org/CVCL_0030"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
                }
              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "19",
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/DDP"
          }
        ],
        "resistance-list": [
          {
            "xref": {
              "accession": "CHEBI_27899",
              "category": "Chemistry resources",
              "database": "ChEBI",
              "iri": "http://purl.obolibrary.org/obo/CHEBI_27899",
              "label": "Cisplatin (CDDP)",
              "url": "https://www.ebi.ac.uk/chebi/search?query=CHEBI_27899"
            }
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
              "label": "Human papillomavirus type 18 (HPV18)",
              "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=333761&lvl=3"
            }
          }
        ],
        "xref-list": [
          {
            "accession": "GDC0057",
            "category": "Cell line collections (Providers)",
            "database": "CCTCC"
          },
          {
            "accession": "Q54882695",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54882695"
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        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_E070"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "value": "Transfected with the Fucci probe which consist of the fusion of monomeric Kusabira-Orange2 (mKO2) to the ubiquitination domain of human CDT1 (aa 30-120) and monomeric AzamiGreen (mAG) to the ubiquitination domain of human geminin (aa 1-110)"
          },
          {
            "category": "Characteristics",
            "value": "Used for study of cell cycle progression thanks to the inclusion of a Fucci (Fluorescent Ubiquitination-based Cell Cycle Indicator) construct"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2012-10-22",
        "derived-from": [
          {
            "accession": "CVCL_0030",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa",
            "url": "https://www.cellosaurus.org/CVCL_0030"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
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                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
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              ]
            }
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        ],
        "disease-list": [
          {
            "accession": "C27677",
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        ],
        "entry-version": "17",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Tyr111_Ile209del",
            "method": "Transfection/transduction",
            "xref": {
              "accession": "HGNC:17493",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "GMNN",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17493"
            }
          },
          {
            "genetic-integration-note": "With p.Met1_Thr29del and p.Ser121_Leu546del",
            "method": "Transfection/transduction",
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              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CDT1",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24576"
            }
          },
          {
            "genetic-integration-note": "mKO2, orange fluorescent protein derived from F.concinna Kusabira-Orange (KO)",
            "method": "Transfection/transduction",
            "xref": {
              "accession": "134NN",
              "category": "Sequence databases",
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              "label": "mKusabira-Orange2",
              "url": "https://www.fpbase.org/protein/134NN/"
            }
          },
          {
            "genetic-integration-note": "Green fluorescent protein from G.fascicularis",
            "method": "Transfection/transduction",
            "xref": {
              "accession": "HC91W",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "AzamiGreen",
              "url": "https://www.fpbase.org/protein/HC91W/"
            }
          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/Fucci"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci #4"
          },
          {
            "type": "synonym",
            "value": "HeLa.S-Fucci"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=18267078"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
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        ],
        "transformant-list": [
          {
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              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
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          }
        ],
        "xref-list": [
          {
            "accession": "CLO_0050931",
            "category": "Cell line databases/resources",
            "database": "CLO",
            "iri": "http://purl.obolibrary.org/obo/CLO_0050931",
            "url": "https://www.ebi.ac.uk/ols4/ontologies/clo/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCLO_0050931"
          },
          {
            "accession": "RCB2812",
            "category": "Cell line collections (Providers)",
            "database": "RCB",
            "url": "https://cellbank.brc.riken.jp/cell_bank/CellInfo/?cellNo=RCB2812&lang=En"
          },
          {
            "accession": "Q54882691",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54882691"
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        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_U187"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "value": "Transfected with the Fucci2 probe which consist of the fusion of mCherry) to the ubiquitination domain of human CDT1 (AA 30-120) and of monomeric Venus (mVenus) to the ubiquitination domain of human geminin (AA 1-110)"
          },
          {
            "category": "Characteristics",
            "value": "Used for study of cell cycle progression thanks to the inclusion of a Fucci2 (Fluorescent Ubiquitination-based Cell Cycle Indicator 2) construct"
          },
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            "value": "African American"
          }
        ],
        "created": "2014-02-03",
        "derived-from": [
          {
            "accession": "CVCL_0030",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa",
            "url": "https://www.cellosaurus.org/CVCL_0030"
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        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
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              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "17",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Tyr111_Ile209del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:17493",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "GMNN",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17493"
            }
          },
          {
            "genetic-integration-note": "With p.Met1_Thr29del and p.Ser121_Leu546del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:24576",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CDT1",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24576"
            }
          },
          {
            "genetic-integration-note": "Bright yellow fluorescent protein derived from GFP",
            "method": "Transfection",
            "xref": {
              "accession": "YUJWJ",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "Venus",
              "url": "https://www.fpbase.org/protein/YUJWJ/"
            }
          },
          {
            "genetic-integration-note": "Red fluorescent protein derived from drFP583 (dsRed)",
            "method": "Transfection",
            "xref": {
              "accession": "ZERB6",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "mCherry",
              "url": "https://www.fpbase.org/protein/ZERB6/"
            }
          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/Fucci2"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci2 #3"
          },
          {
            "type": "synonym",
            "value": "HeLa.S-Fucci2"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(SA)2"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=21226962"
          },
          {
            "resource-internal-ref": "PubMed=29107535"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
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            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "10",
        "genetic-integration-list": [
          {
            "method": "Transfection/transduction",
            "xref": {
              "accession": "P00552",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P00552",
              "label": "Klebsiella pneumoniae transposon Tn5 neo",
              "url": "https://www.uniprot.org/uniprotkb/P00552/entry"
            }
          },
          {
            "genetic-integration-note": "Enhanced GFP",
            "method": "Transfection/transduction",
            "xref": {
              "accession": "R9NL8",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "eGFP",
              "url": "https://www.fpbase.org/protein/R9NL8/"
            }
          }
        ],
        "last-updated": "2025-08-14",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa-Mx2/EGFP C6C3"
          },
          {
            "type": "synonym",
            "value": "HeLa C6C3"
          },
          {
            "type": "synonym",
            "value": "C6C3"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=22373148"
          },
          {
            "resource-internal-ref": "PubMed=27346232"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
              "label": "Human papillomavirus type 18 (HPV18)",
              "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=333761&lvl=3"
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          }
        ],
        "xref-list": [
          {
            "accession": "Q54882523",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54882523"
          }
        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_1H21"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "source-list": [
              {
                "value": "from parent cell line HeLa-P4",
                "xref": {
                  "accession": "CVCL_E8AR",
                  "category": "Cell line databases/resources",
                  "database": "Cellosaurus",
                  "label": "HeLa-P4",
                  "url": "https://www.cellosaurus.org/CVCL_E8AR"
                }
              }
            ],
            "value": "Transfected with a construct pMA175 containing the HIV-1 BRU LTR that allows expression of lacZ when Tat is present (from parent cell line HeLa-P4)"
          },
          {
            "category": "Characteristics",
            "value": "Expression of CD4 is under the control of a mouse PGK promoter (from patent cell line)"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2015-07-08",
        "derived-from": [
          {
            "accession": "CVCL_E8AR",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa-P4",
            "url": "https://www.cellosaurus.org/CVCL_E8AR"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
                }
              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "15",
        "genetic-integration-list": [
          {
            "method": "Transfection",
            "xref": {
              "accession": "P00552",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P00552",
              "label": "Klebsiella pneumoniae transposon Tn5 neo",
              "url": "https://www.uniprot.org/uniprotkb/P00552/entry"
            }
          },
          {
            "method": "Transfection",
            "xref": {
              "accession": "P00722",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P00722",
              "label": "Escherichia coli beta-galactosidase (lacZ)",
              "url": "https://www.uniprot.org/uniprotkb/P00722/entry"
            }
          },
          {
            "method": "Transduction",
            "xref": {
              "accession": "P13249",
              "category": "Sequence databases",
              "database": "UniProtKB",
              "iri": "http://purl.uniprot.org/uniprot/P13249",
              "label": "Streptomyces alboniger pac (PuroR)",
              "url": "https://www.uniprot.org/uniprotkb/P13249/entry"
            }
          },
          {
            "method": "Transduction",
            "xref": {
              "accession": "HGNC:1678",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CD4",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1678"
            }
          },
          {
            "method": "Transduction",
            "xref": {
              "accession": "HGNC:1606",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CCR5",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1606"
            }
          }
        ],
        "last-updated": "2025-08-14",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa-P4-R5 MAGI"
          },
          {
            "type": "synonym",
            "value": "HeLa P4.R5"
          },
          {
            "type": "synonym",
            "value": "P4 MAGI CCR5+"
          },
          {
            "type": "synonym",
            "value": "P4.R5 MAGI"
          },
          {
            "type": "synonym",
            "value": "P4-R5 MAGI"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
          }
        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
              "label": "Human papillomavirus type 18 (HPV18)",
              "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=333761&lvl=3"
            }
          }
        ],
        "xref-list": [
          {
            "accession": "ARP-3580",
            "category": "Cell line collections (Providers)",
            "database": "BEI_Resources",
            "url": "https://www.beiresources.org/Catalog/cellBanks/ARP-3580.aspx"
          },
          {
            "accession": "Q54937291",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q54937291"
          }
        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_VM98"
          }
        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "value": "Transfected with the Fucci(CA)2 probe which consist of the fusion of mCherry to the ubiquitination domain of human CDT1 (aa 1-100) but with the Cy motif 68-RRL-70 replaced by AAA and of monomeric Venus (mVenus) to the ubiquitination domain of human geminin (aa 1-110)"
          },
          {
            "category": "Characteristics",
            "value": "Used for study of cell cycle progression thanks to the inclusion of a Fucci(CA2) (Fluorescent Ubiquitination-based Cell Cycle Indicator) construct"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2018-09-07",
        "derived-from": [
          {
            "accession": "CVCL_0058",
            "category": "Cell line databases/resources",
            "database": "Cellosaurus",
            "label": "HeLa S3",
            "url": "https://www.cellosaurus.org/CVCL_0058"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
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              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "12",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Tyr111_Ile209del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:17493",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "GMNN",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17493"
            }
          },
          {
            "genetic-integration-note": "With p.Ser101_Leu546del and p.Arg68Ala, p.Arg69Ala and p.Leu70Ala",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:24576",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CDT1",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24576"
            }
          },
          {
            "genetic-integration-note": "Bright yellow fluorescent protein derived from GFP",
            "method": "Transfection",
            "xref": {
              "accession": "YUJWJ",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "Venus",
              "url": "https://www.fpbase.org/protein/YUJWJ/"
            }
          },
          {
            "genetic-integration-note": "Red fluorescent protein derived from drFP583 (dsRed)",
            "method": "Transfection",
            "xref": {
              "accession": "ZERB6",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "mCherry",
              "url": "https://www.fpbase.org/protein/ZERB6/"
            }
          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/Fucci(CA)2"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(CA)2 #3"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=29107535"
          }
        ],
        "sex": "Female",
        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
            "iri": "http://purl.obolibrary.org/obo/NCBITaxon_9606",
            "label": "Homo sapiens (Human)",
            "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606&lvl=3"
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        ],
        "transformant-list": [
          {
            "xref": {
              "accession": "333761",
              "category": "Taxonomy",
              "database": "NCBI_TaxID",
              "iri": "http://purl.obolibrary.org/obo/NCBITaxon_333761",
              "label": "Human papillomavirus type 18 (HPV18)",
              "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=333761&lvl=3"
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          }
        ],
        "xref-list": [
          {
            "accession": "RCB4676",
            "category": "Cell line collections (Providers)",
            "database": "RCB",
            "url": "https://cellbank.brc.riken.jp/cell_bank/CellInfo/?cellNo=RCB4676&lang=En"
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            "accession": "Q94101207",
            "category": "Encyclopedic resources",
            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q94101207"
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        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_A7AU"
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        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=37394513"
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              }
            ],
            "value": "Transfected with the Fucci(CA)5 probe which consist of the fusion of AzaleaB5 to the ubiquitination domain of human CDT1 (AA 1-100) but with the Cy motif 68-RRL-70 replaced by AAA and of h2-3 to the ubiquitination domain of human geminin (AA 1-110) (PubMed=37394513)"
          },
          {
            "category": "Characteristics",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=37394513"
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              }
            ],
            "value": "Used for study of cell cycle progression thanks to the inclusion of a Fucci(CA5) (Fluorescent Ubiquitination-based Cell Cycle Indicator) construct (PubMed=37394513)"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2021-05-20",
        "derived-from": [
          {
            "accession": "CVCL_0058",
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            "database": "Cellosaurus",
            "label": "HeLa S3",
            "url": "https://www.cellosaurus.org/CVCL_0058"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
                  "iri": "http://purl.obolibrary.org/obo/UBERON_0000002",
                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
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              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
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            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
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        ],
        "entry-version": "9",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Tyr111_Ile209del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:17493",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "GMNN",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17493"
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          },
          {
            "genetic-integration-note": "With p.Ser101_Leu546del and p.Arg68Ala, p.Arg69Ala and p.Leu70Ala",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:24576",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "CDT1",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24576"
            }
          },
          {
            "genetic-integration-note": "Bright green/yellow fluorescent protein from Ricordea sp. FP2-3",
            "method": "Transfection",
            "xref": {
              "accession": "YQ25V",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "h2-3",
              "url": "https://www.fpbase.org/protein/YQ25V/"
            }
          },
          {
            "genetic-integration-note": "Red fluorescent protein from Montipora monasteriata",
            "method": "Transfection",
            "xref": {
              "accession": "886AH",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "AzaleaB5",
              "url": "https://www.fpbase.org/protein/886AH/"
            }
          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/Fucci(CA)5"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(CA)5 #16"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(CA)5#16"
          }
        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=37394513"
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        ],
        "sex": "Female",
        "species-list": [
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        ],
        "transformant-list": [
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        ],
        "xref-list": [
          {
            "accession": "RCB4919",
            "category": "Cell line collections (Providers)",
            "database": "RCB",
            "url": "https://cellbank.brc.riken.jp/cell_bank/CellInfo/?cellNo=RCB4919&lang=En"
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            "accession": "Q107115324",
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            "database": "Wikidata",
            "url": "https://www.wikidata.org/wiki/Q107115324"
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        ]
      },
      {
        "accession-list": [
          {
            "type": "primary",
            "value": "CVCL_A7AV"
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        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
            "source-list": [
              {
                "reference": {
                  "resource-internal-ref": "PubMed=37394513"
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              }
            ],
            "value": "Transfected with the Fucci(SA)5 probe which consist of the fusion of AzaleaB5 to the ubiquitination domain of human CDT1 (AA 30-120) and of h2-3 to the ubiquitination domain of human geminin (AA 1-110) (PubMed=37394513)"
          },
          {
            "category": "Characteristics",
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              {
                "reference": {
                  "resource-internal-ref": "PubMed=37394513"
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            ],
            "value": "Used for study of cell cycle progression thanks to the inclusion of a Fucci(SA5) (Fluorescent Ubiquitination-based Cell Cycle Indicator) construct (PubMed=37394513)"
          },
          {
            "category": "Population",
            "value": "African American"
          }
        ],
        "created": "2021-05-20",
        "derived-from": [
          {
            "accession": "CVCL_0058",
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            "label": "HeLa S3",
            "url": "https://www.cellosaurus.org/CVCL_0058"
          }
        ],
        "derived-from-site-list": [
          {
            "site": {
              "site-type": "In situ",
              "value": "Uterus, cervix",
              "xref-list": [
                {
                  "accession": "UBERON_0000002",
                  "category": "Anatomy/cell type resources",
                  "database": "UBERON",
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                  "label": "uterine cervix",
                  "url": "https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FUBERON_0000002"
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              ]
            }
          }
        ],
        "disease-list": [
          {
            "accession": "C27677",
            "category": "Medical resources",
            "database": "NCIt",
            "iri": "http://purl.obolibrary.org/obo/NCIT_C27677",
            "label": "Human papillomavirus-related endocervical adenocarcinoma",
            "url": "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27677"
          }
        ],
        "entry-version": "9",
        "genetic-integration-list": [
          {
            "genetic-integration-note": "With p.Tyr111_Ile209del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:17493",
              "category": "Organism-specific databases",
              "database": "HGNC",
              "label": "GMNN",
              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17493"
            }
          },
          {
            "genetic-integration-note": "With p.Met1_Thr29del and p.Ser121_Leu546del",
            "method": "Transfection",
            "xref": {
              "accession": "HGNC:24576",
              "category": "Organism-specific databases",
              "database": "HGNC",
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              "url": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24576"
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          },
          {
            "genetic-integration-note": "Bright green/yellow fluorescent protein from Ricordea sp. FP2-3",
            "method": "Transfection",
            "xref": {
              "accession": "YQ25V",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "h2-3",
              "url": "https://www.fpbase.org/protein/YQ25V/"
            }
          },
          {
            "genetic-integration-note": "Red fluorescent protein from Montipora monasteriata",
            "method": "Transfection",
            "xref": {
              "accession": "886AH",
              "category": "Sequence databases",
              "database": "FPbase",
              "label": "AzaleaB5",
              "url": "https://www.fpbase.org/protein/886AH/"
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          }
        ],
        "last-updated": "2025-04-10",
        "name-list": [
          {
            "type": "identifier",
            "value": "HeLa/Fucci(SA)5"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(SA)5 #16"
          },
          {
            "type": "synonym",
            "value": "HeLa/Fucci(SA)5#16"
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        ],
        "reference-list": [
          {
            "resource-internal-ref": "PubMed=37394513"
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        ],
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        "species-list": [
          {
            "accession": "9606",
            "category": "Taxonomy",
            "database": "NCBI_TaxID",
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        ],
        "transformant-list": [
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      },
      {
        "accession-list": [
          {
            "type": "primary",
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        ],
        "age": "30Y6M",
        "category": "Cancer cell line",
        "child-list": [],
        "comment-list": [
          {
            "category": "Characteristics",
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        ],
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        ],
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        "genetic-integration-list": [
          {
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          },
          {
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        "last-updated": "2025-04-10",
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          {
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              "category": "Organism-specific databases",
              "database": "HGNC",
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        ],
        "disease-list": [
          {
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        ],
        "doubling-time-list": [
          {
            "doubling-time-value": "48-72 hours",
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