ID   AN4;11
AC   CVCL_AY52
SY   AN4-11
DR   Cosmic; 2393013
DR   Wikidata; Q54749899
RX   PubMed=8353274;
RX   PubMed=8358709;
CC   Characteristics: Established from a tumor produced by injection of the leukemic cells into the peritoneum of SCID mice (PubMed=8353274).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (PubMed=8358709).
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8M
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 19-12-24; Version: 8
//
RX   PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080;
RA   Chen, Chien-Shing
RA   Hilden, Joanne M.
RA   Frestedt, Joy
RA   Domer, Peter H.
RA   Moore, Roderick
RA   Korsmeyer, Stanley Joel
RA   Kersey, John H.
RT   "The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal
RT   tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute
RT   leukemia.";
RL   Blood 82:1080-1085(1993).
//
RX   PubMed=8358709;
RA   Hilden, Joanne M.
RA   Chen, Chien-Shing
RA   Moore, Roderick
RA   Frestedt, Joy
RA   Kersey, John H.
RT   "Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the
RT   polymerase chain reaction in t(4;11) acute leukemia.";
RL   Cancer Res. 53:3853-3856(1993).
//