ID   HB11;19
AC   CVCL_8227
SY   HB(11;19); HB11.19; HB 11;19; HB1119
DR   EFO; EFO_0022450
DR   cancercelllines; CVCL_8227
DR   Cell_Model_Passport; SIDM01428
DR   DepMap; ACH-001736
DR   Wikidata; Q54881357
RX   PubMed=1423624;
RX   PubMed=16523483;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7134; MLLT1; Name(s)=KMT2A-MLLT1, MLL-MLLT1, MLL-ENL (PubMed=1423624; PubMed=16523483; DepMap=ACH-001736).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap=ACH-001736).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Met (c.374C>T); ClinVar=VCV000183748; Zygosity=Unspecified (DepMap=ACH-001736).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (DepMap=ACH-001736).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Variations; Array-based CGH.
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 22
//
RX   PubMed=16523483; DOI=10.1002/gcc.20317;
RA   Horsley, Sharon W.
RA   Mackay, Alan
RA   Iravani, Marjan
RA   Fenwick, Kerry
RA   Valgeirsson, Haukur
RA   Dexter, Tim J.
RA   Ashworth, Alan
RA   Kearney, Lyndal
RT   "Array CGH of fusion gene-positive leukemia-derived cell lines reveals
RT   cryptic regions of genomic gain and loss.";
RL   Genes Chromosomes Cancer 45:554-564(2006).
//
RX   PubMed=1423624; DOI=10.1016/0092-8674(92)90602-9;
RA   Tkachuk, Douglas Cameron
RA   Kohler, Sabine
RA   Cleary, Michael L.
RT   "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal
RT   translocations in acute leukemias.";
RL   Cell 71:691-700(1992).
//