ID KOPB-26 AC CVCL_7972 SY KOPB26 DR cancercelllines; CVCL_7972 DR Cosmic; 1150900 DR IARC_TP53; 28408 DR Wikidata; Q54900292 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=1465024; RX PubMed=3491484; RX PubMed=8180386; RX PubMed=9738977; RX PubMed=10360377; RX PubMed=14671638; RX PubMed=20519628; RX PubMed=20575032; RX PubMed=28569787; RX PubMed=29786757; RX PubMed=35124168; CC Population: Japanese. CC Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=14671638). CC Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Leu (c.833C>T); ClinVar=VCV000232497; Zygosity=Unspecified (PubMed=20575032). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283fs (c.849_861delCACAGAGGAAGAG); Zygosity=Unspecified (PubMed=20575032). CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. DI NCIt; C9140; Childhood B acute lymphoblastic leukemia DI NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged DI ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 1Y1M CA Cancer cell line DT Created: 04-04-12; Last updated: 19-12-24; Version: 24 // RX PubMed=20519628; DOI=10.1182/blood-2009-09-244673; RA Hirose, Kinuko RA Inukai, Takeshi RA Kikuchi, Jiro RA Furukawa, Yusuke RA Ikawa, Tomokatsu RA Kawamoto, Hiroshi RA Oram, S. Helen RA Gottgens, Berthold RA Kiyokawa, Nobutaka RA Miyagawa, Yoshitaka RA Okita, Hajime RA Akahane, Koshi RA Zhang, Xiao-Chun RA Kuroda, Itaru RA Honna, Hiroko RA Kagami, Keiko RA Goi, Kumiko RA Kurosawa, Hidemitsu RA Look, Alfred Thomas RA Matsui, Hirotaka RA Inaba, Toshiya RA Sugita, Kanji RT "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription RT factor and its implication in leukemogenesis of B-precursor ALL with RT t(17;19)."; RL Blood 116:962-970(2010). // RX PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068; RA Tamai, Minori RA Kasai, Shin RA Akahane, Koshi RA Thu, Thao Nguyen RA Kagami, Keiko RA Komatsu, Chiaki RA Abe, Masako RA Watanabe, Atsushi RA Goi, Kumiko RA Miyake, Kunio RA Inaba, Toshiya RA Takita, Junko RA Goto, Hiroaki RA Minegishi, Masayoshi RA Iwamoto, Shotaro RA Sugita, Kanji RA Inukai, Takeshi RT "Glucocorticoid receptor gene mutations confer glucocorticoid RT resistance in B-cell precursor acute lymphoblastic leukemia."; RL J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022). // RX PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L; RA Iida, Shinsuke RA Saito, Midori RA Koyama-Okazaki, Toshiko RA Seto, Masao RA Yamamoto, Kazuhito RA Akao, Yukihiro RA Ogura, Michinori RA Suzuki, Hisamitsu RA Ariyoshi, Yutaka RA Koike, Koichi RA Nitta, Masakazu RA Takahashi, Toshitada RA Ueda, Ryuzo RA Nakazawa, Shinpei RT "Phenotypic and genotypic characterization of 14 leukemia and lymphoma RT cell lines with 11q23 translocations."; RL Leuk. Res. 16:1155-1163(1992). // RX PubMed=28569787; DOI=10.1038/cddis.2017.249; PMCID=PMC5520907; RA Kasai, Shin RA Furuichi, Yoshiyuki RA Ando, Norie RA Kagami, Keiko RA Abe, Masako RA Nakane, Takaya RA Goi, Kumiko RA Inukai, Takeshi RA Saitoh, Sei RA Ohno, Shinichi RA Okazaki, Shogo RA Nagano, Osamu RA Saya, Hideyuki RA Sugita, Kanji RT "Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers RT necrosis of B-precursor leukemia cells with high surface CD44 RT expression."; RL Cell Death Dis. 8:e2857.1-e2857.11(2017). // RX PubMed=29786757; DOI=10.1007/s12185-018-2474-7; RA Tomoyasu, Chihiro RA Imamura, Toshihiko RA Tomii, Toshihiro RA Yano, Mio RA Asai, Daisuke RA Goto, Hiroaki RA Shimada, Akira RA Sanada, Masashi RA Iwamoto, Shotaro RA Takita, Junko RA Minegishi, Masayoshi RA Inukai, Takeshi RA Sugita, Kanji RA Hosoi, Hajime RT "Copy number abnormality of acute lymphoblastic leukemia cell lines RT based on their genetic subtypes."; RL Int. J. Hematol. 108:312-318(2018). // RX PubMed=14671638; DOI=10.1038/sj.leu.2403236; RA Drexler, Hans Gunther RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RT "Malignant hematopoietic cell lines: in vitro models for the study of RT MLL gene alterations."; RL Leukemia 18:227-232(2004). // RX PubMed=10360377; DOI=10.1038/sj.leu.2401437; RA Nakamura, Makoto RA Sugita, Kanji RA Inukai, Takeshi RA Goi, Kumiko RA Iijima, Kumiko RA Tezuka, Toshiki RA Kojika, Satoru RA Shiraishi, Kenji RA Miyamoto, Nariaki RA Karakida, Naoko RA Kagami, Keiko RA Koyama-Okazaki, Toshiko RA Mori, Taijiro RA Nakazawa, Shinpei RT "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in RT childhood acute lymphoblastic leukemia with 11q23 translocation."; RL Leukemia 13:884-890(1999). // RX PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886; RA Takizawa, Jun RA Suzuki, Ritsuro RA Kuroda, Hiroyuki RA Utsunomiya, Atae RA Kagami, Yoshitoyo RA Joh, Tatsuroh RA Aizawa, Yoshifusa RA Ueda, Ryuzo RA Seto, Masao RT "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not RT in adult T-cell leukemia."; RL Jpn. J. Cancer Res. 89:712-718(1998). // RX PubMed=3491484; RA Nishino, Kazuyoshi RA Nakazawa, Shinpei RA Mori, Taijiro RA Sugita, Kanji RA Abe, Takashi RA Suzuki, Toshio RA Kinoshita, Akitoshi RA Osano, Mitsuru RA Takane, Keiko RA Migita, Tomofusa RA Hayashi, Yasuhide RA Kawakami, Toshiaki RA Muchi, Hiromu RT "Characterization of KOPB-26 established from the peripheral blood of RT a patient with non-Burkitt's type B-ALL."; RL Nihon Ketsueki Gakkai Zasshi 49:1047-1057(1986). // RX PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455; RA Inukai, Takeshi RA Zhang, Xiu-Ru RA Kameyama, Takeshi RA Suzuki, Yukiko RA Yoshikawa, Kazuhito RA Kuroda, Itaru RA Nemoto, Atsushi RA Akahane, Koshi RA Sato, Hiroki RA Goi, Kumiko RA Nakamoto, Kazunori RA Hamada, Jun-ichi RA Tada, Mitsuhiro RA Moriuchi, Tetsuya RA Sugita, Kanji RT "A specific linkage between the incidence of TP53 mutations and type RT of chromosomal translocations in B-precursor acute lymphoblastic RT leukemia cell lines."; RL Am. J. Hematol. 85:535-537(2010). // RX PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912; RA Yamamoto, Kazuhito RA Seto, Masao RA Iida, Shinsuke RA Komatsu, Hirokazu RA Kamada, Nanao RA Kojima, Seiji RA Kodera, Yoshihisa RA Nakazawa, Shinpei RA Saito, Hidehiko RA Takahashi, Toshitada RA Ueda, Ryuzo RT "A reverse transcriptase-polymerase chain reaction detects RT heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities."; RL Blood 83:2912-2921(1994). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). //