ID SCMC-L1 AC CVCL_7125 AS CVCL_G317 SY SCMC-L-1; SCMCL-L1; Saitama Children's Medical Center-Leukemia 1 DR Cosmic; 998688 DR Cosmic; 1037738 DR Wikidata; Q54952452 RX CelloPub=CLPUB00110; RX CelloPub=CLPUB00111; RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=7647001; RX PubMed=10233379; RX PubMed=10739008; RX PubMed=11226526; RX PubMed=14671638; RX PubMed=29786757; RX PubMed=31305009; RX PubMed=35124168; CC Population: Japanese. CC Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526). CC Sequence variation: Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (PubMed=14671638). CC Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168). CC Omics: Phenotyping; Drug screening. DI NCIt; C9140; Childhood B acute lymphoblastic leukemia DI NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged DI ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 4M CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 23 // RX CelloPub=CLPUB00110; RA Hayashi, Yasuhide RA Hanada, Ryoji RA Moriwaki, Kouichi RA Yamamoto, Keiko RA Imaizumi, Satohiko RA Hirata, Akinari RA Nishida, Toshiro RT "Establishment and characterization of cell lines derived from RT malignant tumors in children."; RL Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991). // RX PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068; RA Tamai, Minori RA Kasai, Shin RA Akahane, Koshi RA Thu, Thao Nguyen RA Kagami, Keiko RA Komatsu, Chiaki RA Abe, Masako RA Watanabe, Atsushi RA Goi, Kumiko RA Miyake, Kunio RA Inaba, Toshiya RA Takita, Junko RA Goto, Hiroaki RA Minegishi, Masayoshi RA Iwamoto, Shotaro RA Sugita, Kanji RA Inukai, Takeshi RT "Glucocorticoid receptor gene mutations confer glucocorticoid RT resistance in B-cell precursor acute lymphoblastic leukemia."; RL J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022). // RX PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x; RA Xu, Feng RA Taki, Tomohiko RA Yang, Hong-Wei RA Hanada, Ryoji RA Hongo, Teruaki RA Ohnishi, Hiroaki RA Kobayashi, Miyuki RA Bessho, Fumio RA Yanagisawa, Masayoshi RA Hayashi, Yasuhide RT "Tandem duplication of the FLT3 gene is found in acute lymphoblastic RT leukaemia as well as acute myeloid leukaemia but not in RT myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in RT children."; RL Br. J. Haematol. 105:155-162(1999). // RX PubMed=29786757; DOI=10.1007/s12185-018-2474-7; RA Tomoyasu, Chihiro RA Imamura, Toshihiko RA Tomii, Toshihiro RA Yano, Mio RA Asai, Daisuke RA Goto, Hiroaki RA Shimada, Akira RA Sanada, Masashi RA Iwamoto, Shotaro RA Takita, Junko RA Minegishi, Masayoshi RA Inukai, Takeshi RA Sugita, Kanji RA Hosoi, Hajime RT "Copy number abnormality of acute lymphoblastic leukemia cell lines RT based on their genetic subtypes."; RL Int. J. Hematol. 108:312-318(2018). // RX PubMed=7647001; DOI=10.1111/j.1365-2141.1995.tb05591.x; RA Ito, Etsuro RA Kasai, Mikio RA Hayashi, Yasuhide RA Toki, Tsutomu RA Arai, Koji RA Yokoyama, Shinkichi RA Kato, Koji RA Tachibana, Naoki RA Yamamoto, Masayuki RA Yokoyama, Masaru RT "Expression of erythroid-specific genes in acute megakaryoblastic RT leukaemia and transient myeloproliferative disorder in Down's RT syndrome."; RL Br. J. Haematol. 90:607-614(1995). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. Res. 24:255-262(2000). // RX PubMed=14671638; DOI=10.1038/sj.leu.2403236; RA Drexler, Hans Gunther RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RT "Malignant hematopoietic cell lines: in vitro models for the study of RT MLL gene alterations."; RL Leukemia 18:227-232(2004). // RX PubMed=31305009; DOI=10.1002/cam4.2356; PMCID=PMC6718581; RA Watanabe, Atsushi RA Inukai, Takeshi RA Kagami, Keiko RA Abe, Masako RA Takagi, Masatoshi RA Fukushima, Takashi RA Fukushima, Hiroko RA Nanmoku, Toru RA Terui, Kiminori RA Ito, Tatsuya RA Toki, Tsutomu RA Ito, Etsuro RA Fujimura, Junya RA Goto, Hiroaki RA Endo, Mikiya RA Look, Thomas RA Kamps, Mark P. RA Minegishi, Masayoshi RA Takita, Junko RA Inaba, Toshiya RA Takahashi, Hiroyuki RA Ohara, Akira RA Harama, Daisuke RA Shinohara, Tamao RA Somazu, Shinpei RA Oshiro, Hiroko RA Akahane, Koshi RA Goi, Kumiko RA Sugita, Kanji RT "Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to RT multiagents in induction therapy."; RL Cancer Med. 8:5274-5288(2019). // RX CelloPub=CLPUB00111; RA Hayashi, Yasuhide RA Kawamura, Machiko RA Kobayashi, Shigetoshi RA Moriwaki, Kouichi RA Kobayashi, Miyuki RA Bessho, Fumio RA Hanada, Ryoji RA Yamamoto, Keiko RA Mori, Taijiro RA Nakazawa, Shinpei RA Yanaginuma, Akihiro RA Honma, Yoshio RA Hozumi, Motoo RT "Establishment and characterization of cell lines derived from RT childhood leukemias."; RL Int. J. Hematol. 57 Suppl. 1:124-124(1993). // RX PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Corrigendum to 'Frequent microsatellite instability and BAX mutations RT in T cell acute lymphoblastic leukemia cell lines' Leukemia Research 24 RT (2000), 255-262."; RL Leuk. Res. 25:275-278(2001). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). //