ID U-937 AC CVCL_0007 SY U937; U 937 DR BTO; BTO_0001412 DR CLO; CLO_0009450 DR CLO; CLO_0009465 DR EFO; EFO_0001257 DR MCCL; MCC:0000470 DR CLDB; cl4597 DR CLDB; cl4599 DR CLDB; cl4600 DR CLDB; cl4601 DR CLDB; cl4602 DR CLDB; cl4603 DR CLDB; cl4604 DR CLDB; cl4605 DR CLDB; cl4606 DR CLDB; cl4608 DR AddexBio; C0003005/72 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR ATCC; CRL-1593 DR ATCC; CRL-1593.2 DR BCRC; 60435 DR BCRJ; 0242 DR BioGRID_ORCS_Cell_line; 154 DR BioSample; SAMN03472409 DR BioSample; SAMN03473173 DR BioSample; SAMN03473567 DR BioSample; SAMN10988180 DR cancercelllines; CVCL_0007 DR CCRID; 1101HUM-PUMC000059 DR CCRID; 3101HUMTCHu159 DR CCRID; 4201HUM-CCTCC00080 DR CCTCC; GDC0080 DR Cell_Model_Passport; SIDM01195 DR ChEMBL-Cells; CHEMBL3308006 DR ChEMBL-Targets; CHEMBL612794 DR CLS; 300368 DR Cosmic; 787483 DR Cosmic; 798666 DR Cosmic; 821044 DR Cosmic; 850382 DR Cosmic; 852000 DR Cosmic; 919123 DR Cosmic; 922162 DR Cosmic; 932770 DR Cosmic; 947364 DR Cosmic; 975307 DR Cosmic; 991558 DR Cosmic; 994178 DR Cosmic; 999781 DR Cosmic; 1012127 DR Cosmic; 1019837 DR Cosmic; 1067446 DR Cosmic; 1070690 DR Cosmic; 1078726 DR Cosmic; 1082516 DR Cosmic; 1086353 DR Cosmic; 1089523 DR Cosmic; 1107178 DR Cosmic; 1127260 DR Cosmic; 1150904 DR Cosmic; 1176581 DR Cosmic; 1181605 DR Cosmic; 1191692 DR Cosmic; 1465967 DR Cosmic; 1523828 DR Cosmic; 1524826 DR Cosmic; 1582388 DR Cosmic; 1601066 DR Cosmic; 1604865 DR Cosmic; 1995661 DR Cosmic; 2301570 DR Cosmic; 2361376 DR Cosmic; 2750876 DR DepMap; ACH-000406 DR DSMZ; ACC-5 DR DSMZCellDive; ACC-5 DR ECACC; 85011440 DR EDITGENE; EDC00301 DR EGA; EGAS00001000610 DR EGA; EGAS00001002554 DR GEO; GSE66854 DR GEO; GSM2020 DR GEO; GSM236809 DR GEO; GSM236845 DR GEO; GSM482491 DR GEO; GSM743413 DR GEO; GSM887724 DR GEO; GSM888818 DR GEO; GSM1028244 DR GEO; GSM1028245 DR GEO; GSM1374975 DR GEO; GSM1670560 DR GEO; GSM7701385 DR GEO; GSM7701386 DR GEO; GSM7701402 DR GEO; GSM7701403 DR Hysigen; TCH-C368 DR IARC_TP53; 2199 DR ICLC; HTL94002 DR IPD-IMGT/HLA; 11507 DR IZSLER; BS TCL 73 DR JCRB; IFO50038 DR JCRB; JCRB9021 DR KCB; KCB 200676YJ DR KCLB; 21593.1 DR LiGeA; CCLE_826 DR LINCS_HMS; 50869 DR LINCS_LDP; LCL-1125 DR Lonza; 135 DR MeSH; D020298 DR NCBI_Iran; C130 DR PharmacoDB; U937_1624_2019 DR PRIDE; PXD001521 DR PRIDE; PXD001522 DR PRIDE; PXD001523 DR Progenetix; CVCL_0007 DR PubChem_Cell_line; CVCL_0007 DR RCB; RCB1978 DR TKG; TKG 0279 DR TOKU-E; 3382 DR Ubigene; YC-C021 DR Wikidata; Q7863610 RX DOI=10.1007/978-1-4757-1647-4_13; RX DOI=10.1007/978-94-011-3550-4_20; RX DOI=10.1016/j.actaastro.2013.06.007; RX DOI=10.1159/000415060; RX PubMed=178611; RX PubMed=1083890; RX PubMed=1571549; RX PubMed=1913629; RX PubMed=2140233; RX PubMed=2243057; RX PubMed=2985879; RX PubMed=3159941; RX PubMed=3874327; RX PubMed=6091813; RX PubMed=6582512; RX PubMed=7759961; RX PubMed=8300570; RX PubMed=8547074; RX PubMed=8558913; RX PubMed=8558920; RX PubMed=8643484; RX PubMed=9371509; RX PubMed=9510473; RX PubMed=9685479; RX PubMed=9738977; RX PubMed=10352142; RX PubMed=10676951; RX PubMed=10739008; RX PubMed=10966170; RX PubMed=11226526; RX PubMed=11416159; RX PubMed=11701946; RX PubMed=12393283; RX PubMed=15637111; RX PubMed=15843827; RX PubMed=16311011; RX PubMed=16337770; RX PubMed=16408098; RX PubMed=16957166; RX PubMed=20801507; RX PubMed=21269460; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=29787063; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=31978347; RX PubMed=33317567; RX PubMed=34707142; RX PubMed=36982453; WW Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/growth-and-morphology-of-atcc-item-crl-1593-2 WW Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=U937 WW Info; HPA; -; https://www.proteinatlas.org/learn/cellines WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-315.html WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/U937_cells WW Provider; NIBSC; 0012; http://www.nibsc.org/Default.aspx?pageid=597&id=0012&theme=default CC Group: Space-flown cell line (cellonaut). CC Problematic cell line: Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: Human Protein Atlas, Cell Atlas panel. CC Part of: LL-100 blood cancer cell line panel. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168. CC Population: Caucasian. CC Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA). CC Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ=ACC-5). CC HLA typing: DRB1*16:01 (IPD-IMGT/HLA=11507). CC HLA typing: A*03:01,03:01; B*18:01,51:01; C*01:02,07:01; DRB1*16:01,16:01 (PubMed=26589293). CC Karyotypic information: Has lost chromosome Y. CC Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526). CC Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (PubMed=8643484; PubMed=25485619). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (PubMed=10966170; DepMap=ACH-000406). CC Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (DepMap=ACH-000406). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=1571549; DepMap=ACH-000406). CC Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (DepMap=ACH-000406). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; Expression; Large antibody panel staining analysis. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=2.39%; East Asian, South=0%; South Asian=0%; European, North=71.54%; European, South=26.06% (PubMed=30894373). CC Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007). CC Discontinued: ATCC; CRL-1593; true. CC Discontinued: RCB; RCB1978; true. CC Discontinued: TKG; TKG 0279; probable. CC Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=11416159; PubMed=15637111; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center ST Amelogenin: X ST CSF1PO: 10,12 (DSMZ=ACC-5; PubMed=15637111) ST CSF1PO: 12 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center) ST D10S1248: 14 ST D12S391: 17,18 ST D13S317: 10,12 ST D16S539: 12 ST D18S51: 13,14 ST D19S433: 14,16 ST D1S1656: 17.3 ST D21S11: 27 (DSMZ=ACC-5; PubMed=15637111) ST D21S11: 27,29 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=25877200; PubMed=34707142; Technion Genomics Center) ST D22S1045: 17 ST D2S1338: 17 (DSMZ=ACC-5) ST D2S1338: 17,20 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=34707142; Technion Genomics Center) ST D2S441: 10 ST D3S1358: 16 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=25877200; PubMed=34707142; Technion Genomics Center) ST D3S1358: 16,17 (DSMZ=ACC-5) ST D5S818: 10,12 (PubMed=15637111) ST D5S818: 10,12,13 (DSMZ=ACC-5) ST D5S818: 12 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center) ST D7S820: 9,11 ST D8S1179: 12,13 ST FGA: 22,25 ST Penta D: 12,13 (ATCC=CRL-1593.2; CLS=300368; COG; PubMed=25877200; Technion Genomics Center) ST Penta D: 13 (DSMZ=ACC-5; PubMed=15637111) ST Penta E: 13 ST TH01: 6,9.3 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; PubMed=11416159; PubMed=15637111; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center) ST TH01: 9.3 (KCLB=21593.1) ST TPOX: 8,11 ST vWA: 14,15 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; PubMed=11416159; PubMed=15637111; PubMed=25877200; RCB=RCB1978; Technion Genomics Center) ST vWA: 15 (KCLB=21593.1; PubMed=34707142) DI NCIt; C8263; Adult acute monocytic leukemia DI ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 37Y CA Cancer cell line DT Created: 04-04-12; Last updated: 25-06-26; Version: 51 CH CVCL_F6BN ! EDITGENE U-937-CopGFP CH CVCL_F5U4 ! EDITGENE U-937-FLUC CH CVCL_3680 ! EL 1 CH CVCL_F1UW ! HyCyte U-937 KO-hCRBN CH CVCL_F1UX ! HyCyte U-937 KO-hIL1RAP CH CVCL_E1N8 ! HyCyte U-937 KO-hPTPRA CH CVCL_F4MX ! HyCyte U-937 stable cell line for hHIF1A overexpression CH CVCL_F4M0 ! HyCyte U-937 stable cell line for hIL1RAP overexpression CH CVCL_E7RW ! iLite Type I IFN Assay Ready Cells CH CVCL_2082 ! JOSK-I CH CVCL_8141 ! JOSK-K CH CVCL_2083 ! JOSK-M CH CVCL_8142 ! JOSK-S CH CVCL_B3XU ! MBU-7 CH CVCL_B3XV ! MBU-8 CH CVCL_8442 ! MOBS-1 CH CVCL_L107 ! PH [Human] CH CVCL_9997 ! SAML-1 CH CVCL_6444 ! SC [Human contaminated U-937] CH CVCL_1775 ! TUR CH CVCL_2810 ! U-937 cl1-14 CH CVCL_2811 ! U-937 cl1-22 CH CVCL_8765 ! U-937 DE-4 CH CVCL_U631 ! U-937 GTB CH CVCL_C8E1 ! U-937 INPP5D KO CH CVCL_WV56 ! U-937 RERC CH CVCL_X000 ! U-937-AG CH CVCL_C8Y0 ! U-937-Luc CH CVCL_WV55 ! U-937/CR CH CVCL_VG84 ! U-M CH CVCL_M769 ! U1/HIV-1 CH CVCL_M770 ! U38 CH CVCL_8927 ! U937(CD59+) CH CVCL_8932 ! U937(CD59-) CH CVCL_E9WW ! U937(G) CH CVCL_E9WX ! U937(V) CH CVCL_A5BW ! U937-ASPI3K CH CVCL_2Z95 ! U937-DC-SIGN CH CVCL_4V23 ! U937/ara-C CH CVCL_Y170 ! U937/clone21 CH CVCL_Y171 ! U937/clone36 CH CVCL_Y172 ! U937/clone41 CH CVCL_Y173 ! U937/clone49 CH CVCL_A5ZK ! U937/EVI1 CH CVCL_X608 ! U937/HIV-2MS CH CVCL_Y174 ! U937/UK110 CH CVCL_Y175 ! U937/UK711 CH CVCL_8466 ! YAA CH CVCL_8467 ! YAP // RX PubMed=12393283; DOI=10.1016/S0165-4608(02)00565-4; RA Lee, Ji-Yun RA Lee, Chul-Hoon RA Shim, Sung Han RA Seo, Han-Kyu RA Kyhm, Jee-Hong RA Cho, Sechin RA Cho, Youl-Hee RT "Molecular cytogenetic analysis of the monoblastic cell line U937: RT karyotype clarification by G-banding, whole chromosome painting, RT microdissection and reverse painting, and comparative genomic RT hybridization."; RL Cancer Genet. Cytogenet. 137:124-132(2002). // RX PubMed=7759961; DOI=10.1002/jlb.57.5.804; RA Reid, Yvonne A. RA McGuire, Linda RA O'Neill, Kathleen RA Macy, Marvin L. RA Chen, Tchaw-Ren RA McClintock, Patrick R. RA Dorotinsky, Catherine S. RA Hay, Robert J. RT "Cell line cross-contamination of U-937."; RL J. Leukoc. Biol. 57:804-804(1995). // RX PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588; RA Hosoya, Noriko RA Hangaishi, Akira RA Ogawa, Seishi RA Miyagawa, Kiyoshi RA Mitani, Kinuko RA Yazaki, Yoshio RA Hirai, Hisamaru RT "Frameshift mutations of the hMSH6 gene in human leukemia cell RT lines."; RL Jpn. J. Cancer Res. 89:33-39(1998). // RX PubMed=10352142; DOI=10.1096/fasebj.13.9001.s23; RA Hatton, Jason P. RA Gaubert, Francois RA Lewis, Marian L. RA Darsel, Yann RA Ohlmann, Philippe RA Cazenave, Jean-Pierre RA Schmitt, Didier RT "The kinetics of translocation and cellular quantity of protein kinase RT C in human leukocytes are modified during spaceflight."; RL FASEB J. 13 Suppl. 1:S23-S33(1999). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX DOI=10.1007/978-1-4757-1647-4_13; RA Biedler, June Lee RT "Chromosome abnormalities in human tumor cells in culture."; RL (In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.359-394; Springer; New York; USA (1975). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=8643484; DOI=10.1073/pnas.93.10.4804; PMCID=PMC39360; RA Dreyling, Martin Heinz RA Martinez-Climent, Jose Angel RA Zheng, Meng RA Mao, Jen-i RA Rowley, Janet Davison RA Bohlander, Stefan Klaus RT "The t(10;11)(p13;q14) in the U937 cell line results in the fusion of RT the AF10 gene and CALM, encoding a new member of the AP-3 clathrin RT assembly protein family."; RL Proc. Natl. Acad. Sci. U.S.A. 93:4804-4809(1996). // RX PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720; RA Mattes, Michael Jules RA Cordon-Cardo, Carlos RA Lewis, John L. Jr. RA Old, Lloyd John RA Lloyd, Kenneth Oliver RT "Cell surface antigens of human ovarian and endometrial carcinoma RT defined by mouse monoclonal antibodies."; RL Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984). // RX PubMed=2243057; DOI=10.1007/BF02624468; RA Kong, Zwe-Ling RA Miwa, Misao RA Murakami, Hiroki RA Shinohara, Kazuki RT "Establishment of a macrophagelike cell line derived from U-937, human RT histiocytic lymphoma, grown serum-free."; RL In Vitro Cell. Dev. Biol. 26:949-954(1990). // RX DOI=10.1016/j.actaastro.2013.06.007; RA Paulsen, Katrin RA Tauber, Svantje RA Golz, Nadine RA Simmet, Dana Michaela RA Engeli, Stephanie RA Birlem, Maria RA Dumrese, Claudia RA Karer, Anissja RA Hunziker, Sandra RA Biskup, Josefine RA Konopasek, Shalimar RA Suh, Durie RA Breuer-Hurlimann, Eva RA Signer, Christoph RA Wang, Anna RA Sang, Chen RA Grote, Karl-Heinrich RA Zhuang, Feng-Yuan RA Ullrich, Oliver RT "Severe disruption of the cytoskeleton and immunologically relevant RT surface molecules in a human macrophageal cell line in RT microgravity -- results of an in vitro experiment on board of the RT Shenzhou-8 space mission."; RL Acta Astronaut. 94:277-292(2013). // RX PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid RT phosphatase."; RL Leuk. Res. 9:537-548(1985). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX DOI=10.1159/000415060; RA Morikawa, Shigeru RA Harada, Takayuki RA Katoh, Taizo RA Nagasaki, Makoto RA Nakano, Hiroko RA Morikawa, Keiko RT "Heterogeneity of cellular origins in human malignant lymphoma cell RT line derived from histo-monocytic lineage cells."; RL (In book chapter) Cellular, molecular, genetic approaches to immunodiagnosis and immunotherapy. 8th International conference on labeled antibodies, Tokyo, November 1985; Kano, Kyoichi & Mori, Shigeo & Sugisaki, Testuzo & Torisu, Motomichi (eds.); pp.373-380; Karger; Basel; Switzerland (1988). // RX PubMed=16311011; DOI=10.1016/j.tiv.2005.10.012; RA Ashikaga, Takao RA Yoshida, Yukiko RA Hirota, Morihiko RA Yoneyama, Katsurako RA Itagaki, Hiroshi RA Sakaguchi, Hitoshi RA Miyazawa, Masaaki RA Ito, Yuichi RA Suzuki, Hiroyuki RA Toyoda, Hidekazu RT "Development of an in vitro skin sensitization test using human cell RT lines: the human Cell Line Activation Test (h-CLAT). I. Optimization RT of the h-CLAT protocol."; RL Toxicol. In Vitro 20:767-773(2006). // RX PubMed=10676951; DOI=10.1038/35000501; RA Alizadeh, Ash Arash RA Eisen, Michael Bruce RA Davis, R. Eric RA Ma, Chi RA Lossos, Izidore S. RA Rosenwald, Andreas RA Boldrick, Jennifer Connolly RA Sabet, Hajeer RA Tran, Truc RA Yu, Xin RA Powell, John I. RA Yang, Li-Ming RA Marti, Gerald E. RA Moore, Troy RA Hudson, James Jr. RA Lu, Li-Sheng RA Lewis, David B. RA Tibshirani, Robert John RA Sherlock, Gavin RA Chan, Wing-Chung RA Greiner, Timothy Charles RA Weisenburger, Dennis D. RA Armitage, James Olen RA Warnke, Roger Allen RA Levy, Ronald RA Wilson, Wyndham H. RA Grever, Michael Rhodes RA Byrd, John C. RA Botstein, David RA Brown, Patrick O'Reilly RA Staudt, Louis Michael RT "Distinct types of diffuse large B-cell lymphoma identified by gene RT expression profiling."; RL Nature 403:503-511(2000). // RX PubMed=9371509; RA Saleem, Ahamed RA Ibrahim, Nageatte RA Patel, Milan RA Li, Xi-Guang RA Gupta, Elora RA Mendoza, John T. RA Pantazis, Panayotis RA Rubin, Eric H. RT "Mechanisms of resistance in a human cell line exposed to sequential RT topoisomerase poisoning."; RL Cancer Res. 57:5100-5106(1997). // RX PubMed=33317567; DOI=10.1186/s13039-020-00517-y; PMCID=PMC7737353; RA MacKinnon, Ruth N. RA Peverall, Joanne RA Campbell, Lynda J. RA Wall, Meaghan RT "Detailed molecular cytogenetic characterisation of the myeloid cell RT line U937 reveals the fate of homologous chromosomes and shows that RT centromere capture is a feature of genome instability."; RL Mol. Cytogenet. 13:50.1-50.14(2020). // RX PubMed=15843827; DOI=10.1038/sj.leu.2403749; RA Hagstrom-Andersson, Anna K. RA Eden, Patrik RA Lindgren, David RA Nilsson, Jens RA Lassen, Carin RA Heldrup, Jesper RA Fontes, Magnus RA Borg, Ake RA Mitelman, Felix RA Johansson, Bertil RA Hoglund, Mattias RA Fioretos, Thoas RT "Gene expression profiling of leukemic cell lines reveals conserved RT molecular signatures among subtypes with specific genetic RT aberrations."; RL Leukemia 19:1042-1050(2005). // RX PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886; RA Takizawa, Jun RA Suzuki, Ritsuro RA Kuroda, Hiroyuki RA Utsunomiya, Atae RA Kagami, Yoshitoyo RA Joh, Tatsuroh RA Aizawa, Yoshifusa RA Ueda, Ryuzo RA Seto, Masao RT "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not RT in adult T-cell leukemia."; RL Jpn. J. Cancer Res. 89:712-718(1998). // RX PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646; RA Quentmeier, Hilmar RA Pommerenke, Claudia RA Dirks, Wilhelm Gerhard RA Eberth, Sonja RA Koeppel, Max RA MacLeod, Roderick A.F. RA Nagel, Stefan RA Steube, Klaus G. RA Uphoff, Cord C. RA Drexler, Hans Gunther RT "The LL-100 panel: 100 cell lines for blood cancer studies."; RL Sci. Rep. 9:8218.1-8218.14(2019). // RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; PMCID=PMC3039570; RA Burkard, Thomas R. RA Planyavsky, Melanie RA Kaupe, Ines RA Breitwieser, Florian P. RA Burckstummer, Tilmann RA Bennett, Keiryn L. RA Superti-Furga, Giulio RA Colinge, Jacques RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17.1-17.13(2011). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=16337770; DOI=10.1016/j.tiv.2005.10.014; RA Sakaguchi, Hitoshi RA Ashikaga, Takao RA Miyazawa, Masaaki RA Yoshida, Yukiko RA Ito, Yuichi RA Yoneyama, Katsurako RA Hirota, Morihiko RA Itagaki, Hiroshi RA Toyoda, Hidekazu RA Suzuki, Hiroyuki RT "Development of an in vitro skin sensitization test using human cell RT lines; human Cell Line Activation Test (h-CLAT). II. An RT inter-laboratory study of the h-CLAT."; RL Toxicol. In Vitro 20:774-784(2006). // RX PubMed=8558920; RA Dirks, Wilhelm Gerhard RA Zaborski, Margarete RA Jager, Kathrin RA Challier, Cecile RA Shiota, Mami RA Quentmeier, Hilmar RA Drexler, Hans Gunther RT "The (2;5)(p23;q35) translocation in cell lines derived from malignant RT lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines."; RL Leukemia 10:142-149(1996). // RX PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x; RA Nakano, Akinobu RA Harada, Takayuki RA Morikawa, Shigeru RA Kato, Yuzuru RT "Expression of leukocyte common antigen (CD45) on various human RT leukemia/lymphoma cell lines."; RL Acta Pathol. Jpn. 40:107-115(1990). // RX PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775; RA Hultdin, Magnus RA Gronlund, Elisabeth RA Norrback, Karl-Frederik RA Eriksson-Lindstrom, E. RA Just, Tom RA Roos, Goran RT "Telomere analysis by fluorescence in situ hybridization and flow RT cytometry."; RL Nucleic Acids Res. 26:3651-3656(1998). // RX PubMed=20801507; DOI=10.1016/j.leukres.2010.07.040; RA Minafra, Luigi RA Di Cara, Gianluca RA Albanese, Nadia Ninfa RA Cancemi, Patrizia RT "Proteomic differentiation pattern in the U937 cell line."; RL Leuk. Res. 35:226-236(2011). // RX PubMed=8558913; RA Morita, Sei RA Tsuchiya, Shigeru RA Fujie, Hiromi RA Itano, Masayuki RA Ohashi, Yoshiyuki RA Minegishi, Masayoshi RA Imaizumi, Masue RA Endo, Mikiya RA Takano, Nagako RA Konno, Tasuke RT "Cell surface c-kit receptors in human leukemia cell lines and RT pediatric leukemia: selective preservation of c-kit expression on RT megakaryoblastic cell lines during adaptation to in vitro culture."; RL Leukemia 10:102-105(1996). // RX PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x; RA Siebert, Reiner RA Willers, Christoph P. RA Schramm, Alexander RA Fossa, Alexander RA Dresen, Irina M. Gana RA Uppenkamp, Michael J. RA Nowrousian, Mohammad Resa RA Seeber, Siegfried RA Opalka, Bertram RT "Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and RT lymphoblastic leukaemia cell lines."; RL Br. J. Haematol. 91:350-354(1995). // RX PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- III. RT Beta-hexosaminidase (E.C. 3.2.1.30)."; RL Leuk. Res. 9:549-559(1985). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. Res. 24:255-262(2000). // RX DOI=10.1007/978-94-011-3550-4_20; RA Shinohara, Kazuki RA Kong, Zwe-Ling RA Murakami, Hiroki RT "Characterization of a human derived macrophage-like cell line, U-M."; RL (In book chapter) Animal cell culture and production of biologicals; Sasaki, Ryuzo & Ikura, Koji (eds.); pp.181-186; Springer; Dordrecht; Netherlands (1991). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=1083890; DOI=10.1084/jem.143.6.1528; PMCID=PMC2190228; RA Ralph, Peter RA Moore, Malcolm A.S. RA Nilsson, Kenneth RT "Lysozyme synthesis by established human and murine histiocytic RT lymphoma cell lines."; RL J. Exp. Med. 143:1528-1533(1976). // RX PubMed=8300570; DOI=10.1016/S0021-9258(17)41964-8; RA Rubin, Eric H. RA Pantazis, Panayotis RA Bharti, Ajit RA Toppmeyer, Deborah RA Giovanella, Beppino Carlo RA Kufe, Donald William RT "Identification of a mutant human topoisomerase I with intact RT catalytic activity and resistance to 9-nitro-camptothecin."; RL J. Biol. Chem. 269:2433-2439(1994). // RX PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123; RA Andersson, Ann-Catrin RA Stromberg, Sara RA Backvall, Helena RA Kampf, Caroline RA Uhlen, Mathias RA Wester, Kenneth RA Ponten, Fredrik RT "Analysis of protein expression in cell microarrays: a tool for RT antibody-based proteomics."; RL J. Histochem. Cytochem. 54:1413-1423(2006). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine Hellenga RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680; RA Skopek, Rafal RA Palusinska, Malgorzata RA Kaczor-Keller, Katarzyna RA Pingwara, Rafal RA Papierniak-Wygladala, Anna RA Schenk, Tino RA Lewicki, Slawomir RA Zelent, Artur RA Szymanski, Lukasz RT "Choosing the right cell line for acute myeloid leukemia (AML) RT research."; RL Int. J. Mol. Sci. 24:5377.1-5377.34(2023). // RX PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059; RA Palumbo, Antonio RA Minowada, Jun RA Erikson, Jan RA Croce, Carlo Maria RA Rovera, Giovanni RT "Lineage infidelity of a human myelogenous leukemia cell line."; RL Blood 64:1059-1063(1984). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14; RA Chanput, Wasaporn RA Peters, Vera RA Wichers, Harry J. RT "THP-1 and U937 cells."; RL (In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.147-159; Springer; Cham; Switzerland (2015). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=178611; DOI=10.1002/ijc.2910170504; RA Sundstrom, Christer RA Nilsson, Kenneth RT "Establishment and characterization of a human histiocytic lymphoma RT cell line (U-937)."; RL Int. J. Cancer 17:565-577(1976). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=15637111; DOI=10.1096/fj.04-3062fje; RA Parson, Walther RA Kirchebner, Romana RA Muhlmann, Roswitha RA Renner, Kathrin RA Kofler, Anita RA Schmidt, Stefan RA Kofler, Reinhard RT "Cancer cell line identification by short tandem repeat profiling: RT power and limitations."; RL FASEB J. 19:434-436(2005). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I; RA Chang, Kenneth S.-S. RA Liu, Wu-Tse RA Josephs, Steven F. RT "Regulation of cellular trans-activating activities in two different RT promonocytic leukemia cell lines."; RL Cancer Lett. 60:75-83(1991). // RX PubMed=34707142; DOI=10.1038/s41598-021-00623-w; PMCID=PMC8551338; RA Maher, Michael RA Diesch, Jeannine RA Le Pannerer, Marguerite-Marie RA Cabezon, Marta RA Mallo, Mar RA Vergara, Sara RA Mendez Lopez, Aleix RA Mesa Tudel, Alba RA Sole, Francesc RA Sorigue, Marc RA Zamora, Lurdes RA Granada, Isabel RA Buschbeck, Marcus RT "Divergent leukaemia subclones as cellular models for testing RT vulnerabilities associated with gains in chromosomes 7, 8 or 18."; RL Sci. Rep. 11:21145.1-21145.11(2021). // RX PubMed=10966170; DOI=10.1034/j.1600-0609.2000.90181.x; RA Aggerholm, Anni RA Gronbaek, Kirsten RA Guldberg, Per RA Hokland, Peter RT "Mutational analysis of the tumour suppressor gene MMAC1/PTEN in RT malignant myeloid disorders."; RL Eur. J. Haematol. 65:109-113(2000). // RX PubMed=16408098; DOI=10.1038/sj.leu.2404081; RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RA Zaborski, Margarete RA Drexler, Hans Gunther RT "JAK2 V617F tyrosine kinase mutation in cell lines derived from RT myeloproliferative disorders."; RL Leukemia 20:471-476(2006). // RX PubMed=11701946; DOI=10.1159/000048774; RA Strefford, Jonathan C. RA Foot, Nicola J. RA Chaplin, Tracy RA Neat, Michael J. RA Oliver, R. Timothy D. RA Young, Bryan Douglas RA Jones, Louise K. RT "The characterisation of the lymphoma cell line U937, using RT comparative genomic hybridisation and multi-plex FISH."; RL Cytogenet. Cell Genet. 94:9-14(2001). // RX PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Corrigendum to 'Frequent microsatellite instability and BAX mutations RT in T cell acute lymphoblastic leukemia cell lines' Leukemia Research 24 RT (2000), 255-262."; RL Leuk. Res. 25:275-278(2001). // RX PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378; RA Sugimoto, Koichi RA Toyoshima, Hideo RA Sakai, Ryuichi RA Miyagawa, Kiyoshi RA Hagiwara, Koichi RA Ishikawa, Fuyuki RA Takaku, Fumimaro RA Yazaki, Yoshio RA Hirai, Hisamaru RT "Frequent mutations in the p53 gene in human myeloid leukemia cell RT lines."; RL Blood 79:2378-2383(1992). //